作者： Ding, Yongbo;Xiao, Yiwei;Ouyang, Qunfu;Luo, Feijun;Lin, Qinlu*

期刊： Ultrasonics Sonochemistry,2021年70:105350 ISSN：1350-4177

通讯作者： Lin, Qinlu

作者机构： [Ding, Yongbo; Luo, Feijun; Ouyang, Qunfu; Xiao, Yiwei; Lin, Qinlu] Cent South Univ Forestry & Technol, Hunan Key Lab Processed Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Natl Engn Lab Rice & Prod Deep Proc,Coll Food Sci, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Lin, Qinlu] C;Cent South Univ Forestry & Technol, Hunan Key Lab Processed Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Natl Engn Lab Rice & Prod Deep Proc,Coll Food Sci, Changsha 410004, Hunan, Peoples R China.

关键词： Chemically modified starch;In vitro starch digestibility;Structural changes;Ultrasonic treatment;Non-thermal processing technology

摘要： Chemically modified starch (RS4) was commercially available as a food ingredient, however, there was a lack of knowledge on how ultrasonic treatment (non-thermal technology) modulated the enzymatic resistance of RS4. In this study, structural change of RS4 during ultrasonic treatment and its resulting digestibility was investigated. Results from scanning electron microscopy, particle size analysis, chemical composition analysis, X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy showed that ultrasonic treatment remained the granule morphology, increased the apparent amylose content, reduced the particle size, destroyed the crystalline structure, decreased the helical orders, but enhanced the short-range molecular orders of ultrasonic-processed RS4. In vitro digestibility analysis showed that the total content of rapidly digestible starch and slowly digestible starch was increased, whereas the content of resistant starch was decreased. Overall, ultrasonic treatment substantially reduced the enzymatic resistance of RS4, indicating that RS4 was not stability against the non-thermal processing technology of ultrasonic treatment.

语种： 英文

作者： Deng, Jing;Chen, Qi Jue;Li, Wen*;Zuberi, Zavuga;Feng, Jian Xiang;...

期刊： Journal of Materials Science,2021年56(10):5995-6015 ISSN：0022-2461

通讯作者： Li, Wen

作者机构： [Lin, Qin Lu; Deng, Jing; Li, Wen; Ren, Jia Li; Luo, Fei Jun] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Prov Key Lab Edible Forestry Resources Safe, Coll Food Sci & Engn,Hunan Key Lab Processed Food, Changsha 410004, Hunan, Peoples R China.;[Zeng, Xiao Xi; Ma, Liang; Deng, Jing; Chen, Qi Jue; Feng, Jian Xiang; Zheng, Xiang Min; Li, Wen; Ding, Quan Ming] Hunan Univ Technol, Coll Life Sci & Chem, Coll Packaging & Mat Engn, Zhuzhou 412007, Hunan, Peoples R China.;[Zuberi, Zavuga] Dar Es Salaam Inst Technol, Dept Sci & Lab Technol, POB 2958, Dar Es Salaam, Tanzania.;[Yin, Hua Qun] Cent South Univ, Sch Resource Proc & Bioengn, Changsha 410083, Hunan, Peoples R China.

通讯机构： [Li, Wen] C;[Li, Wen] H;Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Prov Key Lab Edible Forestry Resources Safe, Coll Food Sci & Engn,Hunan Key Lab Processed Food, Changsha 410004, Hunan, Peoples R China.;Hunan Univ Technol, Coll Life Sci & Chem, Coll Packaging & Mat Engn, Zhuzhou 412007, Hunan, Peoples R China.

关键词： Cyclodextrins;Molecules;Targeted drug delivery;Cyclodextrin cavities;Drug encapsulation;Hydrophilic and hydrophobic;Multifunctional properties;Natural materials;Pharmaceutical industry;Recent progress;Small molecules;Controlled drug delivery

摘要： Abstract: Cyclodextrins are a type of natural materials that can be used in the pharmaceutical industry. Cyclodextrins are safe, biodegradable, with the multifunctional property as they can encapsulate both hydrophilic and hydrophobic drugs. Additionally, they can overcome challenges associated with drug toxicity and enhancing the solubility of the insoluble drugs; thus, cyclodextrins are effective carriers in loading tiny molecules. Moreover, the synthesis of nanosponges (NPs) systems can enhance the drug encapsulation in cyclodextrin cavities to control the rate of drug released. Cyclodextrin can contain the drug molecules to form a clathrate; cyclodextrin-based NPs can maintain a high loading capacity of various small molecules for drug delivery. This review presents a general overview of the current research progress and the applications of cyclodextrin-based NPs for drug delivery in the past two decades. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

语种： 英文

作者： Li, Wen;Liu, Yu;Li, Zi Jin;Shi, Yi;Deng, Jing*;...

期刊： Biomolecules,2021年11(2):1-17 ISSN：2218-273X

通讯作者： Chen, Zhu;Deng, Jing;Da, Fu

作者机构： [Shi, Yi; Ma, Liang; Zeng, Xiao Xi; Liu, Yu; Rong, Duo Yan; Chen, Zhu; Li, Wen; Feng, Shan Shan] Hunan Univ Technol, Coll Life Sci & Chem, Zhuzhou 412007, Peoples R China.;[Deng, Jing; Li, Zi Jin; Li, Wen; Ren, Jia Li; Da, F; Da, Fu; Chen, Xiao Qi; Bai, Jie; Luo, Fei Jun] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.;[Yin, Hua Qun] Cent South Univ, Sch Resource Proc & Bioengn, Changsha 410083, Peoples R China.;[Da, Fu] Tongji Univ, Sch Med, Cent Lab Med Res, Shanghai Peoples Hosp 10, Shanghai 200072, Peoples R China.

通讯机构： [Chen, Zhu] H;[Deng, J; Da, F] C;[Da, Fu] T;Hunan Univ Technol, Coll Life Sci & Chem, Zhuzhou 412007, Peoples R China.;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

关键词： CeRNA network;LUAD;Prognosis;WT1-AS/miR-206/NAMPT axis

摘要： Lung cancer is the world’s highest morbidity and mortality of malignant tumors, with lung adenocarcinoma (LUAD) as a major subtype. The competitive endogenous RNA (ceRNA) regulative network provides opportunities to understand the relationships among different molecules, as well as the regulative mechanisms among them in order to investigate the whole transcriptome landscape in cancer pathology. We designed this work to explore the role of a key oncogene, MYC, in the pathogenesis of LUAD, and this study aims to identify important long noncoding RNA (lncRNA)-microRNA (miRNA)-transcription factor (TF) interactions in non-small cell lung cancer (NSCLC) using a bioinformatics analysis. The Cancer Genome Atlas (TCGA) database, containing mRNA expression data of NSCLC, was used to determine the deferentially expressed genes (DEGs), and the ceRNA network was composed of WT1-AS, miR-206, and nicotinamide phosphoribosyltransferase (NAMPT) bashing on the MYC expression level. The Kaplan–Meier univariate survival analysis showed that these components may be closely related prognostic biomarkers and will become new ideas for NSCLC treatment. Moreover, the high expression of WT1-AS and NAMPT and low expression of miR-206 were associated with a shortened survival in NSCLC patients, which provided a survival advantage. In summary, the current study constructing a ceRNA-based WT1-AS/miR-206/NAMPT axis might be a novel important prognostic factor associated with the diagnosis and prognosis of LUAD. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

语种： 英文

作者： Ding, Yongbo;Liang, Ying;Luo, Feijun;Ouyang, Qunfu;Lin, Qinlu*

期刊： Carbohydrate Polymers,2020年228:115350 ISSN：0144-8617

通讯作者： Lin, Qinlu

作者机构： [Ding, Yongbo; Luo, Feijun; Ouyang, Qunfu; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Natl Engn Lab Rice & Byprod Deep Proc,Hunan Key L, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Lin, Qinlu] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Natl Engn Lab Rice & Byprod Deep Proc,Hunan Key L, Changsha 410004, Hunan, Peoples R China.

关键词： In vitro digestibility;Regulation;Resistant starch;Structural properties;Ultrasonic treatment

摘要： The digestibility properties and structural changes of retrograded starch (RS3) induced by ultrasonic treatment (UT) were investigated. The digestion profiles showed that UT increased the slowly digestible starch (SDS) or resistant starch (RS) of RS3 as an effective green process, corresponding to a change in hydrolysis kinetic parameters (equilibrium starch hydrolysis percentage and kinetic constant). SEM analysis showed that ultrasound led to breakage of RS3 particles followed by cracking, reorientation and crystallization. Differences in amylose content, granule size, and ζ-potential were found for native RS3 and ultrasound-treated RS3 (UT-RS3). UT decreased the relative crystallinity and gelatinization enthalpy but enhanced short-range order of RS3 based on the results of XRD, DSC, and FT-IR, respectively. Surprisingly, diffractive peaks at 13°and 20° (V-type crystalline structure) and a new exothermic peak were also observed for UT-RS3. The outcome was believed to open new pathways for regulating the digestibility properties of RS3 by UT and development of low glycemic response food. © 2019 Elsevier Ltd

语种： 英文

作者： Tang, Wenjie;Wu, Jian;Jin, Shunshun;He, Liuqin*;Lin, Qinlu;...

期刊： 中国科学:生命科学(英文版),2020年63(1):116-124 ISSN：1674-7305

通讯作者： He, Liuqin;Li, Tiejun

作者机构： [Yin, Yulong; Tang, Wenjie; He, Liuqin] Hunan Normal Univ, Coll Life Sci, Lab Anim Nutr & Human Hlth, Hunan Int Joint Lab Anim Intestinal Ecol & Hlth, Changsha 410081, Peoples R China.;[Wu, Jian; Li, Tiejun; Yin, Yulong; He, Liuqin; Jin, Shunshun] Chinese Acad Sci, Hunan Prov Key Lab Anim Nutrit Physiol & Metab Pr, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China.;[Luo, Feijun; Lin, Qinlu; He, Liuqin] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Hunan Key Lab Proc Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod,Hunan Key L, Changsha 410004, Peoples R China.;[He, Binsheng; Bing, Pingping] Changsha Med Univ, Affiliated Hosp 1, Acad Working Stn, Changsha 410219, Peoples R China.;[Tang, Wenjie] Sichuan Acad Anim Sci, Anim Breeding & Genet Key Lab Sichuan Prov, Chengdu 610066, Peoples R China.

通讯机构： [He, Liuqin] H;[He, LQ; Li, TJ; He, Liuqin] C;Hunan Normal Univ, Coll Life Sci, Lab Anim Nutr & Human Hlth, Hunan Int Joint Lab Anim Intestinal Ecol & Hlth, Changsha 410081, Peoples R China.;Chinese Acad Sci, Hunan Prov Key Lab Anim Nutrit Physiol & Metab Pr, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China.;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Hunan Key Lab Proc Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod,Hunan Key L, Changsha 410004, Peoples R China.

关键词： glutamate;aspartate;boars;oxidative stress;inflammatory cytokines

摘要： Several potential oxidative agents have damaging effects on mammalian reproductive systems. This study was conducted to investigate the effects of glutamate (Glu) and aspartate (Asp) supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H 2 O 2 . A total of 24 healthy boars were randomly divided into 4 treatment groups: control (basal diet, saline-treated), H 2 O 2 (basal diet, H 2 O 2 -challenged outer scrotum (1 mL kg −1 BW)), Glu (basal diet +2% Glu, H 2 O 2 -challenged), and Asp (basal diet+2% Asp, H 2 O 2 -challenged). Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H 2 O 2 -treated boars. Glu and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone levels. Furthermore, the mRNA expression of CAT, CuZnSOD, and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu. Glu and Asp supplementation also modulated the expression of TGF-β1, IL-10, TNF-α, IL-6 and IL-1β in the testis and epididymis. These results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress. © 2019, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

语种： 英文

作者： 周潇恬;罗非君

期刊： 现代食品,2020年5(10):66-71 ISSN：2096-5060

作者机构： 中南林业科技大学食品科学与工程学院稻谷及副产物深加工国家工程实验室,湖南 长沙 410004;[罗非君; 周潇恬] 中南林业科技大学

关键词： 苦瓜;化学成分;生理功能;抗炎;降脂

摘要： 苦瓜中含有蛋白质、多糖、黄酮类、三萜类、皂苷类、类固醇和生物碱类等多种营养成分,目前研究表明苦瓜具有抗氧化、抗菌、降脂、降血压、抗病毒、抗炎、抗肿瘤、抗溃疡、抗癌和免疫调节等生理作用.本文全面综述了近年来苦瓜的活性成分及其生物学功能的研究进展,为进一步深入研究苦瓜生理功能和功能性食品的开发提供参考.

语种： 中文

作者： Sun, Shuguo;Zhao, Juanhong;Luo, Zhang;Lin, Qinlu;Luo, Feijun;...

期刊： Journal of Food Science and Technology,2020年57(4):1351-1361 ISSN：0022-1155

通讯作者： Yang, Tao

作者机构： [Luo, Feijun; Yang, Tao; Zhao, Juanhong; Sun, Shuguo; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha Engn Res Ctr Food Storage & Preservat,Hu, Hunan Key Lab Processed Food Special Med Purpose, Changsha 410004, Hunan, Peoples R China.;[Luo, Zhang] Tibet Agr & Anim Husb Univ, Coll Food Sci, Lingzhi 860000, Tibet, Peoples R China.;[Luo, Feijun] Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge, England.

通讯机构： [Yang, Tao] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn,Natl Engn Lab Deep Proc Rice, Changsha Engn Res Ctr Food Storage & Preservat,Hu, Hunan Key Lab Processed Food Special Med Purpose, Changsha 410004, Hunan, Peoples R China.

关键词： Yak meat;Deterioration index;Volatile compounds;Headspace solid-phase microextraction

摘要： In this study, the physicochemical properties (total volatile basic nitrogen (TVB-N), pH, and peroxide value) and the volatile flavors of yak meat were systematically evaluated during chilled (0 degrees C) and controlled freezing-point (- 2 degrees C) storage. The TVB-N reached 15.21 mg/100 g after 18 days of storage at 0 degrees C, which exceeded the secondary freshness value according to the Chinese national standard. For storage at - 2 degrees C, the TVB-N did not exceed 15 mg/100 g until 24 days. Compared with storage at 0 degrees C, the samples stored at - 2 degrees C had a slower rate of increase in TVB-N, pH, and peroxide values. The changes in volatile compounds in yak meat during storage at - 2 degrees C and 0 degrees C for 24 days were investigated using headspace solid-phase microextraction (HS-SPME) followed by gas chromatography-mass spectrometry (GC-MS). The correlations between the changes in the volatile compound contents and meat quality deterioration revealed significant negative correlations (r(min) = 0.902, p < 0.05) between some aldehyde flavor components (nonanal, heptanal, benzaldehyde, decanal, and myristal) and TVB-N in the samples stored at controlled freezing-point and chilled temperatures. The decreases in nonanal, benzaldehyde, and myristal contents in yak meat followed zero order reaction kinetics. This result indicated, because of the highly selective and sensitive colorimetric detection method, that volatile compounds can effectively predict the decay in quality of yak meat stored at low temperature in advance. Thus, based on physicochemical and volatile flavor analyses, a new method is proposed to investigate the storage and preservation of yak meat.

语种： 英文

作者： Peng, Xianglian*;Fu, Hongjun;Hu, Jinbo;Luo, Feijun

期刊： Journal of Food Science,2020年85(4):1186-1192 ISSN：0022-1147

通讯作者： Peng, Xianglian

作者机构： [Luo, Feijun; Peng, Xianglian; Fu, Hongjun] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.;[Hu, Jinbo] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Peng, Xianglian] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

关键词： mercury;plastic;devices;food contamination;food packaging;food safety;temperature;Food Contamination;Food Packaging;Food Safety;Mercury;Plastics;Temperature

摘要： The understanding of the migration of mercury from packaging materials to food stuffs is the prerequisite for the development of food safety regulations. In this article, the migration of mercury from food paper-plastic packaging containers to four food stimulants under different migrated temperatures is studied. The results show that the mobility and the maximum migration volume of mercury increase at certain temperatures when the migration time is extended. It is also noted that the time to reach equilibrium is reduced as the temperature increases. Meanwhile, different solvents appear various different while the rates of migration are 3% acetic acid >10%ethanol >20%ethanol >50%ethanol. But they show the same trend at the different temperatures. Our data suggest that different solvents, temperatures, and food stimulants affect the migration rates, and ameliorate those conditions will reduce migration and promote food quality. © 2020 Institute of Food Technologists®

语种： 英文

作者： Zhou, Liyi*;Luo, Feijun;Chi, Weijie;Tang, Yiping;Liu, Xiaogang;...

期刊： Sensors and Actuators B-Chemical,2020年311:127915 ISSN：0925-4005

通讯作者： Zhou, Liyi;Lin, Qinlu

作者机构： [Zhou, Liyi; Luo, Feijun; Tang, Yiping; Lin, Qinlu] Cent South Univ Forestry & Technol Changsha, Hunan Key Lab Processed Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Changsha 410004, Hunan, Peoples R China.;[Chi, Weijie; Liu, Xiaogang] Singapore Univ Technol & Design, 8 Somapah Rd, Singapore 487372, Singapore.;[Zhou, LY; Lin, Qinlu] Cent South Univ Forestry & Technol, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Zhou, LY; Lin, QL] C;Cent South Univ Forestry & Technol, Changsha 410004, Hunan, Peoples R China.

关键词： Selenium-containing;Fluorescent apoptotic agent;Cancer cell apoptosis;Bioimaging

摘要： Activation of cancer cell apoptosis and understanding its working mechanism play a critical role in formulating effective cancer treatment strategies. Herein, we report the design, synthesis, and biological evaluations of a selenium-containing fluorescent apoptotic agent MPSE. MPSE enabled the tracking and imaging of cancer cell apoptosis process. Its emission at 550 nm turned off in the presence of thioredoxin reductase (TrxR) in mitochondria, by forming a non-emissive compound MP. This emission "turn-off" phenomenon allows the monitoring of reactive oxygen species (ROS) induced mitochondria damages. As dysfunctional mitochondria were removed by lysosomes, MP entered lysosomes and its protonation led to bright emissions peaked at 475 nm. The new emission enables the tracking of lysosome activation during the apoptosis process. With the help of MPSE, along with other biological techniques, we have revealed three signal transduction pathways that activate cancer cell apoptosis and inhibit tumor cell proliferation. Our results showed that MPSE was highly useful in elucidating the working mechanism of theranostic-based optical apoptotic agents. We hope that understanding this mechanism will greatly facilitate the development of new cancer treatments.

语种： 英文

作者： Xu, Lina;Guo, Weidan;Liu, Weicong;Fu, Xiangjin*;Wu, Yue;...

期刊： Food Chemistry,2020年303:125368 ISSN：0308-8146

通讯作者： Fu, Xiangjin

作者机构： [Guo, Weidan; Luo, Feijun; Liu, Weicong; Wu, Yue; Fu, Xiangjin; Xu, Lina; Xu, Youzhi] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Fu, Xiangjin] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

关键词： 2-phenylethanol (PubChem CID: 6054);Allose (PubChem CID: 439507);Antioxidant;Arabinose (PubChem CID: 5460291);Bio-preservative;Cedrol (PubChem CID: 65575);Cold-resistant;Dulcitol (PubChem CID: 11850);Erythritol (PubChem CID: 222285);Glycerol (PubChem CID: 753);Isolongifolene (PubChem CID: 11127402);Lipid oxidation;Mannobiose (PubChem CID: 152109);Metabolite;Threose (PubChem CID: 439665);Thymol-glucoside (PubChem CID: 88687);Turanose(PubChem CID: 5460935);Wickerhamomyces anomalus;Xylitol (PubChem CID: 6912);ridine(PubChem CID: 6029)

摘要： The effect of eight cold-resistant yeast strains (J3, J7, J8, J9, J12, J15, J18, and J25) of Wickerhamomyces anomalus on the lipid oxidation of cold stored fish mince (4 degrees C) were investigated. And the metabolites of these yeast were determined with gas chromatography-mass spectrometry. These strains could effectively inhibit the increase of hydroperoxides value (p<0.05), and the inhibiting rate was positively correlated with the content of isolongifolene, xylitol, turanose, thymol-glucoside, and uridine. Especially, the J3, J7, J8, J9, J12, and J18 could eliminate a large part of thiobarbituric acid reactive substances (TBARS) (p<0.05), the eliminating rate was proportionate to the aldehyde dehydrogenase activity. Several bacteriostatic metabolites were detected: thymol-glucoside, 2-phenylethanol, cedro, and 2,4-bis (1,1-dimethylethyl) phenol. In addition, W. anomalus produced many metabolites with fruit and floral notes. In conclusion, cold-resistant W. anomalus strains own antioxidant activity were potential new bio-preservatives in the cold storage of muscle products.

语种： 英文

作者： 徐魏;罗非君

期刊： 生命的化学,2019年39(5):1013-1018 ISSN：1000-1336

作者机构： 中南林业科技大学食品科学与工程学院,稻谷及副产物深加工国家工程实验室,长沙410004;湖南食品药品职业学院,食品学院,长沙410208;[罗非君; 徐魏] 中南林业科技大学

关键词： 生育三烯酚;心血管病;动脉粥样硬化;胆固醇

摘要： 心血管疾病是全球主要的病死原因,对其进行防治具有重要的意义。生育三烯酚是维生素E的主要成分之一,具有抗氧化、降胆固醇、抗炎和抗肿瘤等多种生物学活性。近年来,大量研究表明,生育三烯酚在抗动脉粥样硬化、改善心肌缺血后再灌注损伤、降血压、抑制心血管炎症等方面具有较好的效果。本文针对近年来生育三烯酚对心血管疾病的防治研究进行综述,概述了生育三烯酚对心血管疾病的保护作用及其分子机理,旨在为生育三烯酚在心血管疾病防治方面的应用提供参考。

语种： 中文

作者： Liu, Chun;Luo, Lijuan;Wu, Ying;Yang, Xiaoquan;Dong, Jie;...

期刊： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019年67(8):2255-2264 ISSN：0021-8561

通讯作者： Lin, Qinlu

作者机构： [Dong, Jie; Luo, Feijun; Liu, Chun; Luo, Lijuan; Wu, Ying; Lin, Qinlu] Ctr South Univ Forestry & Technol, Sch Food Sci & Engn, Hunan Key Lab Proc Food Special Med Purpose, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.;[Yang, Xiaoquan] South China Univ Technol, Sch Food Sci & Engn, Res & Dev Ctr Food Prot, Guangzhou 510640, Guangdong, Peoples R China.;[Dong, Jie] Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China.;[Zou, Yuan] South China Agr Univ, Sch Food Sci, Guangzhou 510642, Guangdong, Peoples R China.;[Shen, Yingbin] Jinan Univ, Sch Sci & Engn, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China.

通讯机构： [Lin, Qinlu] C;Ctr South Univ Forestry & Technol, Sch Food Sci & Engn, Hunan Key Lab Proc Food Special Med Purpose, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

关键词： Sugar (sucrose);inactivation;interaction;Soy milk;soybean Bowman?Birk inhibitor;Steviosides;Hydrogen bonds;Bowman Birk inhibitor;food additive;glucoside;kaurane derivative;stevioside;sweetening agent;chemistry;kinetics;molecular docking;soybean;soybean milk;Diterpenes, Kaurane;Food Additives;Glucosides;Kinetics;Molecular Docking Simulation;Soy Milk;Soybeans;Sweetening Agents;Trypsin Inhibitor, Bowman-Birk Soybean

摘要： In this work, the interaction of the soybean Bowman-Birk inhibitor (BBI) with stevioside (STE) was studied by stopped-flow-fluorescence and molecular docking. STE's inactivation of protease-inhibitor activities in soymilk and the influence of STE addition on the sensory character of soymilk were also evaluated. The results indicate that STE binds BBI with a binding constant (K a ) of 3.38 × 10 5 L mol -1 to form a 1:1 complex. The docking study reveals that two hydrogen bonds are formed between the side-chain of Lys16 (reactive site 1) of BBI and the glucose-ring hydroxyl groups of STE, which may block BBI from contacting trypsin and thus deactivate the trypsin-inhibitor activity (TIA) of BBI. Moreover, the residual TIA in soymilk could also be inactivated by STE. A mixture of 159 mg/L STE and 60 g/L sucrose could be used for sweetening soymilk without affecting the sensory characteristics when compared to a reference product sweetened with 9% sucrose. © 2019 American Chemical Society.

语种： 英文

作者： Shen, Junjun;Luo, Feijun*;Lin, Qinlu*

期刊： Journal of Functional Foods,2019年57:351-360 ISSN：1756-4646

通讯作者： Luo, Feijun;Lin, Qinlu

作者机构： [Luo, Feijun; Shen, Junjun; Lin, Qinlu] Cent South Univ Forestry & Technol, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Proc Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod,Coll Food S, Changsha 410004, Hunan, Peoples R China.;[Luo, FJ; Lin, Qinlu; Shen, Junjun] Cent South Univ Forestry & Technol, Coll Life Sci & Biotechnol, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Luo, FJ; Lin, QL] C;Cent South Univ Forestry & Technol, Coll Life Sci & Biotechnol, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

关键词： Bioavailability;Dietary supplementation;Extraction methods;Functional foods;Health-improving activities;Policosanol

摘要： Policosanol is widely distributed naturally and can be isolated and purified from rice bran, sugarcane, apples, grapes etc. Due to its functional significance and ease of bioavailability, techniques for the extraction of policosanol are of great significance to investigators, of which saponification, solvent extraction, transesterification, molecular distillation, supercritical carbon dioxide extraction, ultrasonic-assisted extraction and other extraction methods are evaluated. Policosanol has been usually applied in functional foods because it has multiple health-improving properties, including the lowering of lipids, anti-aging, tissue regeneration, cyto-, liver, cardiovascular and cerebrovascular protection, and protection against diabetes, hypercholesterolemia, Parkinson's disease, inflammation, ulcers and cancer. Additionally, the signaling pathways AMPK, MAPK and PI3K/Akt involved in its effects are investigated. This review compiled the most interesting references for scientifics engaged in policosanol health-improving effects, including extraction procedures. To sum up, it will help to develop ancillary drugs and functional foods in the future. © 2019 Elsevier Ltd

语种： 英文

作者： Ding, Yongbo;Luo, Feijun;Lin, Qinlu*

期刊： Food Chemistry,2019年294:248-259 ISSN：0308-8146

通讯作者： Lin, Qinlu

作者机构： [Ding, Yongbo; Luo, Feijun; Lin, Qinlu] Cent South Univ Forestry & Technol, Hunan Key Lab Processed Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Natl Engn Lab Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Lin, Qinlu] C;Cent South Univ Forestry & Technol, Hunan Key Lab Processed Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Natl Engn Lab Rice & Byprod, Changsha 410004, Hunan, Peoples R China.

关键词： Digestibility;Molecular structure;Retrograded starch;Ultrasonic treatment

摘要： In this study, ultrasound was used to modulate the molecular structure of retrograded starch (RS3) responsible for the digestion properties, and the relationships among the ultrasonic power, molecular structure, and RS3 digestibility were revealed. Results revealed that the morphological characteristics of RS3 changed after ultrasonic treatment, and high power resulted in more compact block-shape structure. The results of particle size analysis, Fourier transform infrared spectroscopy, and X-ray diffraction showed that ultrasound decreased the long-range orders but increased the median particle size, short-range orders, and V-type polymorph of ultrasound-treated RS3. A decreased (double helix of amylopectin) and an increased (single helix of V-amylose) enthalpy change were observed by differential scanning calorimeter. Digestion profiles showed that some fractions of rapidly-digestible starch were converted into slowly-digestible starch and/or resistant starch. This study provides a potential approach to regulate the digestion of starch-rich foods with desired digestibility through ultrasonic treatment.

语种： 英文

作者： Sun, Shuguo;Li, Beiping;Yang, Tao;Luo, Feijun;Zhao, Juanhong;...

期刊： Journal of Cereal Science,2019年85:279-285 ISSN：0733-5210

通讯作者： Lin, Qinlu

作者机构： [Luo, Feijun; Yang, Tao; Zhao, Juanhong; Cao, Jianzhong; Li, Beiping; Sun, Shuguo; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China.;[Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Lin, Qinlu] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

关键词： Controlled atmosphere storage;Mechanism;Molecular modeling tools;Paddy rice

摘要： Use of carbon dioxide controlled atmospheres has proven to be effective for the preservation of cereal grain during storage, but its preservation mechanisms remain to be fully elucidated. In this study, preservation mechanism of high concentration carbon dioxide controlled atmosphere for paddy rice storage was evaluated based on quality analyses and a novel method using molecular modeling tools. During 90 days storage, the fat acidity, cooked rice hardness, and lipoxygenase activity of paddy rice were gradually increased and alpha-amylase activity was decreased rapidly, but the degree of change of the paddy rice stored in controlled atmosphere was lower than that in non-controlled atmosphere. The rate constants for hydration water disaggregation from biological macromolecules, such as proteins and starch in paddy rice, and isothermal kinetic parameters were calculated according to simple first-order kinetics and the Arrhenius's law. The hydration water of paddy rice stored in non-controlled atmosphere presented the higher rate constant for degradation, especially at higher temperatures. Values of activation energies were 28.27 and 15.80 kJ/mol, respectively, for hydration water of paddy rice stored in controlled and non-controlled atmosphere. The mechanism of controlled atmospheres for paddy rice preservation may be the higher of activation energies for hydration water or biological macromolecules. © 2018

语种： 英文

作者： Xu, Lina;Luo, Yu;Fu, Xiangjin*;Luo, Feijun;Xu, Youzhi;...

期刊： FOOD SCIENCE & NUTRITION,2019年7(7):2404-2411 ISSN：2048-7177

通讯作者： Fu, Xiangjin

作者机构： [Luo, Feijun; Luo, Yu; Fu, Xiangjin; Xu, Lina; Sun, Shuguo; Xu, Youzhi] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

通讯机构： [Fu, Xiangjin] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.

关键词： carbonyl compounds;docosahexaenoic acid (DHA);eicosapentaenoic acid (EPA);flavor;lipid oxidation;Saccharomyces uvarum;silver carp

摘要： Fish lipid is highly susceptible to oxidation, resulting in accumulation of toxic substances reactive carbonyl compounds (RCCs), the reduction of nutritional value, and the production of odorous substances. In this study, the effect of yeast (Saccharomyces uvarum) on RCCs, fat acid composition, volatiles, and sensory traits in silver carp mince stored at 4°C was evaluated. Yeast eliminated malondialdehyde, 4-hydroxyl-2-hexenal, and 4-hydroxyl-2-nonenal by about 80%, 68%, and 60%, which increased by about 170%, 340%, and 300% in the control, respectively. Yeast helped retain about 80% of the polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively; only about 53% and 46% of EPA and DHA, respectively, were maintained in the control. Yeast removed off-odors hexanal, nonanal, and decenal, resulting in enhanced sensory traits. These findings were economically important for improving the quality of fish products. It might present an approach to improve the flavor of fish products. © 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc.

语种： 英文

作者： 刘晶;郭婷;郭天一;邹佳文;周潇恬;...

期刊： 食品与机械,2019年35(1):32-40 ISSN：1003-5788

作者机构： 湘南学院化学生物与环境工程学院,湖南郴州 423000;中南林业科技大学食品科学与工程学院粮油深加工与品质控制湖南省重点实验室,湖南长沙410004;中南林业科技大学食品科学与工程学院粮油深加工与品质控制湖南省重点实验室,湖南长沙,410004;中南林业科技大学食品科学与工程学院稻谷及副产物深加工国家工程实验室,湖南长沙410004;[罗非君; 周潇恬; 郭婷; 何洁; 邹佳文; 郭天一; 石雨虹] 中南林业科技大学

关键词： 米糠;多糖;炎症;炎症因子

摘要： 以3％葡聚糖硫酸钠(DSS)为诱导剂建立ICR小鼠结肠炎症模型,评估米糠多糖的抗炎功效与分子机理.采用病理组织分析、RT-qPCR和Western blotting等多种技术比较各组动物组织的病理改变和基因表达的差异.结果 发现:给予500 mg/(kg·d)米糠多糖灌胃能明显改善结肠炎症小鼠的整体健康状况,降低疾病活动指数分数,减轻小鼠结肠炎症组织的损伤,改善炎症相关生化指标.RT-qPCR分析发现,米糠多糖可使结肠组织炎症因子TNFα、IL-1β、Cox-2和iNOS等基因mRNA表达水平下调,Western blotting分析进一步证实了米糠多糖抑制炎症因子蛋白表达水平的功效,同时,米糠多糖也能抑制MAPK信号通路.结果 表明米糠多糖具有抗炎作用,其分子机制可能与下调炎症因子的表达和阻断MAPK信号通路相关.

语种： 中文

作者： 徐魏;罗非君

期刊： 生命科学,2019年31(10):1077-1087 ISSN：1004-0374

作者机构： 中南林业科技大学食品科学与工程学院,稻谷及副产物深加工国家工程实验室,长沙410004;湖南食品药品职业学院食品学院,长沙410208;[罗非君; 徐魏] 中南林业科技大学

关键词： 芹菜素;生物活性;作用机理

摘要： 芹菜素是一种广泛存在于各类蔬菜水果中的天然黄酮类化合物,具有多种生物学活性。该文主要从抗肿瘤、心血管保护、抗神经退行性疾病、抗2型糖尿病以及安全性等方面阐述和探讨其作用机制,为芹菜素在这些疾病中的潜在应用提供新的思路和依据。

语种： 中文

作者： Liu, Jun;Guo, Ting;Luo, Yunchuan;Chai, Xueying;Wu, Jingyan;...

期刊： Bioresource Technology,2019年272:552-560 ISSN：0960-8524

通讯作者： Lin, Qinlu

作者机构： [Luo, Feijun; Guo, Ting; Wu, Jingyan; Chai, Xueying; Zhao, Wen; Liu, Jun; Luo, Yunchuan; Lin, Qinlu] Cent South Univ Forestry & Technol, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Processed Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod,Coll Food S, Changsha 410004, Hunan, Peoples R China.;[Jiao, Pengfei] Nanyang Normal Univ, Sch Life Sci & Technol, 1638 Wolong Rd, Nanyang 473061, Henan, Peoples R China.

通讯机构： [Lin, Qinlu] C;Cent South Univ Forestry & Technol, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Hunan Key Lab Processed Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod,Coll Food S, Changsha 410004, Hunan, Peoples R China.

关键词： Immobilized-cells;Monascus pigments;Response surface methodology;Simultaneous fermentation process and separation

摘要： A mutant Monascus purpureus strain, M183, which produced monascus pigments (MPs) at 8460 U/g via solid-state batch-fermentation, was generated using the atmospheric and room temperature plasma (ARTP) mutation system. The optimal glucose concentration (80 g/L) in traditional fermentation media that yielded the highest MPs productivity was determined. Response surface methodology (RSM) was applied to maximize MPs production using liquid-state batch-fermentation. Under optimal conditions (0.58 g/L MgSO4·7H2O, 0.02 g/L ZnSO4·7H2O, 0.02 g/L FeSO4·7H2O and 4.85 g/L NH4NO3), 207.67 U/mL of MPs were produced with 98.12% validity based on the predicted value. Extracellular MPs production increased significantly to 35.52 U/mL, compared to 14.19 U/mL of the original strain, M. purpureus LQ-6. M. purpureus spores immobilized in sodium alginate were studied. A simultaneous fermentation and separation system was established for MPs using the novel absorption resin LX300C to enhance production efficiency of extracellular MPs. © 2018 Elsevier Ltd

语种： 英文

作者： 徐魏;雷艳琴;魏湘芝;吕淑贞;罗非君

期刊： 食品安全质量检测学报,2018年9(11):2775-2779 ISSN：2095-0381

作者机构： 中南林业科技大学食品科学与工程学院,长沙410004;湖南食品药品职业学院食品学院,长沙410208;湖南食品药品职业学院食品学院,长沙,410208;中南林业科技大学食品科学与工程学院,长沙,410004;[罗非君; 徐魏] 中南林业科技大学

关键词： 紫花地丁;芹菜素;抗氧化;稳定性;DPPH自由基

摘要： 目的 研究不同外界因素对紫花地丁芹菜素抗氧化稳定性的影响.方法 紫花地丁芹菜素标准品经乙醇溶解,采用清除DPPH自由基法测定其抗氧化活性,研究不同pH、温度、光照条件、一些常见金属离子及防腐剂对样品抗氧化性的影响.结果 紫花地丁芹菜素具有较强的耐热性;在酸性环境中抗氧化活性保持较好,在碱性环境中抗氧化活性很快丧失;金属离子(Na+、K+、Ca2+、Mg2+)对紫花地丁芹菜素的稳定性影响不明显,而光照、山梨酸钾则会降低其活性.结论 外界环境因素对紫花地丁芹菜素抗氧化能力存在不同程度的影响,建立合适的储存条件可以显著增强紫花地丁芹菜素的抗氧化能力.

语种： 中文