Activatable selenium-containing fluorescent apoptotic agent for biosensing and tracing cancer cell apoptosis

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成果类型：

期刊论文

作者：

Zhou, Liyi*;Luo, Feijun;Chi, Weijie;Tang, Yiping;Liu, Xiaogang;...

通讯作者：

Zhou, Liyi;Lin, Qinlu

作者机构：

[Zhou, Liyi; Luo, Feijun; Tang, Yiping; Lin, Qinlu] Cent South Univ Forestry & Technol Changsha, Hunan Key Lab Processed Food Special Med Purpose, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Changsha 410004, Hunan, Peoples R China.

[Chi, Weijie; Liu, Xiaogang] Singapore Univ Technol & Design, 8 Somapah Rd, Singapore 487372, Singapore.

[Zhou, LY; Lin, Qinlu] Cent South Univ Forestry & Technol, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Zhou, LY; Lin, QL] C

Cent South Univ Forestry & Technol, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Selenium-containing;Fluorescent apoptotic agent;Cancer cell apoptosis;Bioimaging

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2020

卷：

311

页码：

127915

DOI：

10.1016/j.snb.2020.127915

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21605046]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ3060]; grain-oil process and quality control 2011 collaborative and innovative grant from Hunan Province [448]; Singapore University of Technology and Design (SUTD)Singapore University of Technology & Design; SUTD-MIT International Design CentreSingapore University of Technology & Design [T1SRCI17126, IDD21700101, IDG31800104]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Activation of cancer cell apoptosis and understanding its working mechanism play a critical role in formulating effective cancer treatment strategies. Herein, we report the design, synthesis, and biological evaluations of a selenium-containing fluorescent apoptotic agent MPSE. MPSE enabled the tracking and imaging of cancer cell apoptosis process. Its emission at 550 nm turned off in the presence of thioredoxin reductase (TrxR) in mitochondria, by forming a non-emissive compound MP. This emission "turn-off" phenomenon allows the monitoring of reactive oxygen species (ROS) induced mitochondria ...

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Activatable selenium-containing fluorescent apoptotic agent for biosensing and tracing cancer cell apoptosis

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