摘要：
Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development, disease diagnosis, and basic theoretical research. Aminopeptidase N (APN), as a representative tumor biomarker with anti-tumor potential, still lacks a high-precision theranostic probe specifically targeting it. In this study, a novel quaternity design strategy for APN theranostic probe was developed. This proposed strategy utilizes advanced machine learning and molecular dynamics simulations, and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi -objective optimization and integration of functional fragments. Through this strategy, a unique "Off-On" theranostic probe, ABTP-DPTB, was ingeniously constructed to light up APN through fluorescence restoration, relying on conformation-induced effects and solvent restriction. Differ from the common diagnostic probes, the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ imag-ing. The fabricated probe was used for detecting and inhibiting APN in various environments, with a better in vitro inhibitory than golden-standard drug bestatin.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
通讯机构：
[Lu Lu] S;School of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan Province, PR China<&wdkj&>National Engineering Research Center for Rice and By-product Deep Processing, Changsha 410004, Hunan Province, PR China<&wdkj&>Hunan Key Laboratory of Processed Food for Special Medical Purpose, Changsha 410004, Hunan Province, PR China
摘要：
The development of cereal foods with slow starch digestibility is important for the general improvement of human health. In this study, the quality properties of noodles with added okara, in vitro starch digestibility, and the underlying mechanisms of the influence of okara on noodles were studied. Low concentrations (5 and 10 %) of okara improved the texture, cooking, and sensory properties of the noodles. Okara decreased the rapidly digestible starch (RDS) content, increased the resistant starch (RS) content, and reduced the predicted glycaemic index (pGI) of noodles. The pasting viscosity, thermal stability, and dynamic rheological results indicated that okara improved the starch crystallite stability of wheat flour and viscoelasticity of dough. Moreover, Fourier transform infrared (FTIR) spectroscopy showed that okara promoted the formation of starch-lipid complexes and improved the short-range structural order of starch. Additionally, microstructure imaging and protein network analysis (PNA) indicated that low addition of okara promoted the compactness of the okara-gluten-starch matrix, thus reducing the contact between starch and hydrolytic enzymes. These results reveal the effect of okara on the quality properties and starch digestibility in a starch-gluten complex system.
期刊：
Chemical Engineering Journal,2023年470:144044 ISSN：1385-8947
通讯作者：
Dong Xu
作者机构：
[Zhou, Rongju; Luo, Hongmei; Peng, Chenzhan; Guo, Xin; Xu, Dong; Lin, Qinlu] National Engineering Laboratory for Rice and By-products Further Processing, College of Food Science and Engineering, Central South University of Forestry & Technology, Changsha 410004, China;[Zhao, Tian] Hunan School of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou 412007, China;[Du, Yi] Analysis Center, Department of Chemistry, Tsinghua University, Beijing 100084, China
通讯机构：
[Dong Xu] N;National Engineering Laboratory for Rice and By-products Further Processing, College of Food Science and Engineering, Central South University of Forestry & Technology, Changsha 410004, China
摘要：
Precise control of morphology is crucial for achieving sophisticated properties and advanced applications of nanomaterials. Among different shapes, concave nanomaterials have emerged as a novel class of unconventional materials with superior properties in comparison to their convex counterparts, owing to abundant atomic steps and kinks. Here, we report rapid (10 min) one-pot synthesis of concave gold nanocubes (CGNs) with tunable indentations and high-index facets, using a combination of ascorbic acid (AA) and H2O2. The synthesis of CGNs involved the reduction of Au3+ to Au+ by H2O2 under alkaline conditions, followed by initiating CGN formation upon the addition of AA. Cyclic voltammetry scanning confirmed that AA and H2O2 co-participate in the reduction of Au+. The concentrations of H2O2 and AA were precisely controlled to adjust the indentation and high-index facets, such as {7 3 0}, {6 1 0}, {3 1 0}, {8 3 0}, etc. The concave structures of CGNs were formed due to Au0 deposition on {1 1 1} facets at the tips for AA and {1 0 0} facets at the surface center for H2O2. Remarkably, the typical CGNs with {7 3 0} facets exhibited higher catalytic activity towards the reduction of nitrophenol by NaBH4 than many other Au nanomaterials, with an unusual kinetic profile, i.e., an increasing reaction rate.
期刊：
Journal of Environmental Management,2023年347:119118 ISSN：0301-4797
通讯作者：
Li, Wen;Lin, QL
作者机构：
[He, Jintao; Xia, Suxuan; Deng, Jing; Lin, Qinlu; Li, Wen; Zhang, Lin] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & Byproduct Deep Proc, Hunan Prov Key Lab Edible Forestry Resources Safet, Changsha 410004, Hunan, Peoples R China.;[Li, Wen] Hunan Prov Engn Technol Res Ctr Seasonings Green M, Changsha 410004, Peoples R China.;[Li, Wen; Lin, Qinlu] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Nanjing 210023, Jiangsu, Peoples R China.
通讯机构：
[Lin, QL ; Li, W] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & Byproduct Deep Proc, Hunan Prov Key Lab Edible Forestry Resources Safet, Changsha 410004, Hunan, Peoples R China.
关键词：
Added value compounds;Carbon neutrality;Food wastewater;Resource recovery;Sustainability;Wastewater treatment
摘要：
The food processing industry is one of the world's largest consumers of potable water. Agri-food wastewater systems consume about 70% of the world's fresh water and cause at least 80% of deforestation. Food wastewater is characterized by complex composition, a wide range of pollutants, and fluctuating water quality, which can cause huge environmental pollution problems if discharged directly. In recent years, food wastewater has attracted considerable attention as it is considered to have great prospects for resource recovery and reuse due to its rich residues of nutrients and low levels of harmful substances. This review explored and compared the sources and characteristics of different types of food wastewater and methods of wastewater treatment. Particular attention was paid to the different methods of resource recovery and reuse of food wastewater. The diversity of raw materials in the food industry leads to different compositional characteristics of wastewater, which determine the choice and efficiency of wastewater treatment methods. Physicochemical methods, and biological methods alone or in combination have been used for the efficient treatment of food wastewater. Current approaches for recycling and reuse of food wastewater include culture substrates, agricultural irrigation, and bio-organic fertilizers, recovery of high-value products such as proteins, lipids, biopolymers, and bioenergy to alleviate the energy crisis. Food wastewater is a promising substrate for resource recovery and reuse, and its valorization meets the current international policy requirements regarding food waste and environment protection, follows the development trend of the food industry, and is also conducive to energy conservation, emission reduction, and economic development. However, more innovative biotechnologies are necessary to advance the effectiveness of food wastewater treatment and the extent of resource recovery and valorization.
作者机构：
[Liu, Xiaobo] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & By Prod, Changsha, Hunan, Peoples R China.;[Li, Ruichao] Yangzhou Univ, Inst Comparat Med, Coll Vet Med, Yangzhou, Jiangsu, Peoples R China.;[Chan, Edward Wai-Chi] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chem Biol & Drug Discovery, Hong Kong, Peoples R China.;[Chen, Sheng] City Univ Hong Kong, Jockey Club Coll Vet Med & Life Sci, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China.;[Chen, Sheng] City Univ Hong Kong Shenzhen Res Inst, Shenzhen, Peoples R China.
通讯机构：
[Sheng Chen] D;Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR<&wdkj&>City University of Hong Kong Shenzhen Research Institute, Shenzhen, China
关键词：
resistance genes;foodborne E. coli;phage;genetic analysis;virulence genes
摘要：
Bacterial antimicrobial resistance, especially phenotypic resistance to multiple drugs (MDR), has posed a serious threat to public health worldwide. To clarify the mechanism of transmission of multidrug resistance encoding plasmids in Enterobacterales, all seven plasmids of an Escherichia coli (E. coli) strain 1108 obtained from a chicken meat sample were extracted and sequenced by Illumina Nextseq 500 and MinION platforms. Plasmids in strain 1108 possessed 16 known antimicrobial resistance genes, with p1108-NDM (similar to 97K) being the most variable plasmid. The multidrug resistance region of p1108-NDM was punctuated by eight IS26 insertion sequences; thus, four MDR regions were found in the backbone of this plasmid. The plasmid p1108-MCR (similar to 65K) was found to lack the ISApl1 element and harbor the bla(CTX-M-64)-ISEcp1 transposition unit. Moreover, the ISEcp1-bla(CMY-2) transposition unit was found in plasmid p1108-CMY2 (similar to 98K), whereas plasmid p1108-emrB (similar to 102K) was associated with resistance to erythromycin (emrB) and streptomycin (aadA22). p1108-IncY (96K) was a phage P1-like plasmid, while p1108-IncFIB (similar to 194K) was found to harbor a virulence region similar to ColV plasmids, and they were found to encode a conserved conjugative transfer protein but harbor no resistance genes. Finally, no mobile element and resistant genes were found in p1108-ColV (similar to 2K). Carriage of mcr-1-encoding elements in carbapenemase-producing Escherichia coli will potentially render all antimicrobial treatment regimens ineffective. Enhanced surveillance and effective intervention strategies are urgently needed to control the transmission of such multidrug resistance plasmids.IMPORTANCE Antimicrobial resistance (AMR) has been increasingly prevalent in agricultural and clinical fields. Understanding the genetic environment involved in AMR genes is important for preventing transmission and developing mitigation strategies. In this study, we investigated the genetic features of an E. coli strain (1108) isolated from food product and harboring 16 AMR genes, including bla(NDM-1) and mcr-1 genes encoding resistance to last line antibiotics, meropenem, and colistin. Moreover, this strain also carried virulence genes such as iroBCDEN, iucABCD, and iutA. Our findings confirmed that multiple conjugative plasmids that were formed through active recombination and translocation events were associated with transmission of AMR determinants. Our data warrant the continuous monitoring of emergence and further transmission of these important MDR pathogens.
摘要：
Lipids are crucial components for the maintenance oof normal structure and function in the nervous system. Elucidating the diversity of lipids in spinal cords may contribute to our understanding of neurodevelopment. This study comprehensively analyzed the fatty acid (FA) compositions and lipidomes of the spinal cords of eight domesticated animal species: pig, cattle, yak, goat, horse, donkey, camel, and sika deer. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) were the primary FAs in the spinal cords of these domesticated animals, accounting for 72.54-94.23% of total FAs. Notably, oleic acid, stearic acid and palmitic acid emerged as the most abundant FA species. Moreover, untargeted lipidomics by UPLC-Q-Exactive Orbitrap-MS demonstrated that five lipid classes, including glycerophospholipids (GPs), sphingolipids (SPs), glycerolipids (GLs), FAs and saccharolipids (SLs), were identified in the investigated spinal cords, with phosphatidylcholine (PC) being the most abundant among all identified lipid classes. Furthermore, canonical correlation analysis showed that PC, PE, TAG, HexCer-NS and SM were significantly associated with genome sequence data. These informative data provide insight into the structure and function of mammalian nervous tissues and represent a novel contribution to lipidomics.
作者机构：
[Zhang, Biao; Ding, Yongbo; Jiang, Yuling; Chen, Huirong; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn,Natl Engn Res Ctr Rice & Byp, Hunan Key Lab Forestry Edible Sources Safety & Pr, Hunan Key Lab Processed Food Special Med Purpose, Changsha 410004, Hunan, Peoples R China.;[Fang, Yong] Nanjing Univ Finance & Econ, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Coll Food Sci & Engn, Nanjing 210023, Peoples R China.
通讯机构：
[Yongbo Ding] N;National Engineering Research Center of Rice and Byproduct Deep Processing, Hunan Key Laboratory of Processed Food for Special Medical Purpose, Hunan Key Laboratory of Forestry Edible Sources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, 410004 China
摘要：
Starch type affects the structural and digestibility properties of OCSNPs, OPtSNPs, and OPSNPs, with the most obvious effect observes for OPtSNPs. Abstract This study characterizes the digestibility properties and structural changes of octenyl succinic anhydride (OSA) modified starch nanoparticles (OSPNs) from corn, potato, and pea starches (codes as OCSNPs, OPtSNPs, and OPSNPs). After OSA modification, the average particle size and degree of substitution of OSPNs significantly (p < 0.05) increase compared to control samples, whereas the apparent amylose content, R1047/1022, relative crystallinity, and melting enthalpy are found to decrease significantly (p < 0.05), with the extent depending on the type of starch. In vitro digestibility tests show that OSA treatment converts part of rapidly digestible starch into slowly digestible starch and resistant starch for OSPNs, an effect that is more pronounced for OPtSNPs compared to OCSNPs and OPSNPs, corresponding to a reduce in equilibrium starch hydrolysis percentage and apparent digestion rate coefficient. Overall, the starch type affects the structural and digestibility properties of OCSNPs, OPtSNPs, and OPSNPs, with the most obvious effect observes for OPtSNPs.
通讯机构：
[Liang, Y ] C;Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & Byproduct Deep Proc, Mol Nutr Branch, Changsha 410004, Hunan, Peoples R China.
关键词：
atherosclerosis;ingredients from food medicine homology;macrophage polarization;nutritional intervention
摘要：
The polarization of macrophages plays a crucial regulatory role in a range of physiological and pathological processes involving macrophages. There are numerous concerns with macrophage polarization in atherosclerosis; however, most focus on modulating macrophage polarization to improve the microenvironment, and the mechanism of action remains unknown. In recent years, the advantages of natural and low-toxicity side effects of food medicine homology-derived substances have been widely explored. Few reports have started from ingredients from food medicine homology to regulate the polarization of macrophages so that early intervention can reduce or delay the process of atherosclerosis. This review summarizes the classification of macrophage polarization and related markers in the process of atherosclerosis. It summarizes the regulatory role of ingredients from food medicine homology in macrophage polarization and their possible mechanisms to provide ideas and inspiration for the nutritional intervention in vascular health.
摘要：
Rapid economic growth and urbanization have led to significant changes in the world's consumption patterns. Accelerated urbanization, the spread of the mobile Internet, and the increasing pace of work globally have all contributed to the demand for the food takeaway industry. The rapid development of the takeaway industry inevitably brings convenience to life, and with it comes great environmental pressure from waste packaging materials. While maintaining the convenience of people's lives, further reducing the environmental pollution caused by takeaway packaging materials and promoting the recycling and reuse of takeaway packaging waste need to attract the attention and concern of the whole society. This review systematically and comprehensively introduces common takeaway food types and commonly used packaging materials, analyzes the impacts of discarded takeaway packaging materials on human health and the ecological environment, summarizes the formulation and implementation of relevant policies and regulations, proposes treatment methods and resourceful reuse pathways for discarded takeaway packaging, and also provides an outlook on the development of green takeaway packaging. Currently, only 20% of waste packaging materials are recycled worldwide, and there is still a need to develop more green takeaway packaging materials and continuously improve relevant policies and regulations to promote the sustainable development of the takeaway industry. The review is conducive to further optimizing the takeaway packaging management system, alleviating the environmental pollution problem, and providing feasible solutions and technical guidance for further optimizing takeaway food packaging materials and comprehensive utilization of resources.
作者：
Guan, Chunmin;Long, Xinkang;Long, Zhao;Lin, Qinlu;Liu, Chun
期刊：
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,2023年58(1):300-314 ISSN：0950-5423
通讯作者：
Chun Liu
作者机构：
[Guan, Chunmin; Long, Zhao; Long, Xinkang; Liu, Chun; Lin, Qinlu] Cent South Univ Forestry & Technol, Sch Food Sci & Engn, Natl Engn Res Ctr Rice & By Prod Deep Proc, Changsha 410004, Peoples R China.
通讯机构：
[Chun Liu] N;National Engineering Research Center for Rice and By-product Deep Processing, School of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004 China
关键词：
3D printing;extruded rice products;legumes components;legumes flour;nutritional properties;physiological functions
摘要：
In recent years, legumes have become increasingly popular because of their high nutritional value and health benefits. Moreover, most legumes have a low glycaemic index (GI) and are often considered in dietary interventions for diabetes. Extruded rice products (ERPs) are trendy in major rice-producing areas, including staple foods (such as rice noodles) and snack foods (such as rice cake). However, ERPs have a higher GI and a relatively simple nutritional composition. Therefore, adding whole legumes flour or its components to ERPs is a significant issue, which can reduce ERPs' GI and improve these products' nutritional value. This paper reviewed the nutritional properties and physiological functions of legumes flour or its components. In addition, the factors (starch and extrusion processing) affecting the quality and GI of ERPs were summarised. Besides, this paper reviewed after adding whole legumes flour or its components to ERPs, the products' appearance and quality are better and its nutritional properties are also better, especially with regard to type 2 diabetes mellitus (T2DM). Moreover, this review also summarised three-dimensional (3D) printing technology in ERPs could improve the products' quality and nutritional value. Finally, directions that will be the focus of 3D printing and legumes were highlighted.
