作者机构:
College of Science, Hunan Province Key Laboratory of Materials Surface & Interface Science and Technology, Central South University of Forestry and Technology, Changsha , Hunan, China;College of Science, Jiujiang University, Jiujiang , Jiangxi, China;[Mengdong He; Yuxiang Peng; Wei Li; Jianbo Li; Peihao Su; Exian Liu; Kaijun Wang] College of Science, Hunan Province Key Laboratory of Materials Surface & Interface Science and Technology, Central South University of Forestry and Technology, Changsha , Hunan, China;[Jianqiang Liu] College of Science, Jiujiang University, Jiujiang , Jiangxi, China
摘要:
The immunity of topological states against backscattering and structural defects provides them with a unique advantage in the exploration and design of high-precision low-loss optical devices. However, the operating bandwidth of the topological states in certain photonic structures is difficult to actively tune and flexibly reconfigure. In this study, we propose a valley topological photonic crystal (TPC) comprising two inverse honeycomb photonic crystals, consisting of hexagonal silicon and Ge2Sb2Te5 (GST) rods. When GST transitions from the amorphous phase to the crystalline phase, the edge band of the TPC appears as a significant redshift and is inversed from a"∪"to an"∩"shape with topological phase transition, which enables active tuning of the operating bandwidth and propagation direction of topological edge states. Both the topological edge and corner states in a triangular structure constructed using TPCs can be simultaneously adjusted and reconfigured via GST phase transition, along with a change in the group number of corner states. Using the adjustability of topological edge states and electromagnetic coupling between two different topological bearded interfaces, we develop a multichannel optical router with a high tuning degree of freedom, where channels can be actively reconfigured and their on/off states can be freely switched. Our study provides a strategy for the active regulation of topological states and may be beneficial for the development of reconfigurable topological optical devices. The immunity of topological states against backscattering and structural defects provides them with a unique advantage in the exploration and design of high-precision low-loss optical devices. However, the operating bandwidth of the topological states in certain photonic structures is difficult to actively tune and flexibly reconfigure. In this study, we propose a valley topological photonic crystal (TPC) comprising two inverse honeycomb photonic crystals, consisting of hexagonal silicon and Ge2Sb2Te5 (GST) rods. When GST transitions from the amorphous phase to the crystalline phase, the edge band of the TPC appears as a significant redshift and is inversed from a"∪"to an"∩"shape with topological phase transition, which enables active tuning of the operating bandwidth and propagation direction of topological edge states. Both the topological edge and corner states in a triangular structure constructed using TPCs can be simultaneously adjusted and reconfigured via GST phase transition, along with a change in the group number of corner states. Using the adjustability of topological edge states and electromagnetic coupling between two different topological bearded interfaces, we develop a multichannel optical router with a high tuning degree of freedom, where channels can be actively reconfigured and their on/off states can be freely switched. Our study provides a strategy for the active regulation of topological states and may be beneficial for the development of reconfigurable topological optical devices.
作者机构:
[Liu, Dongbo; Zhang, Zhixu] State Key Lab Subhlth Intervent Technol, Changsha 410128, Hunan, Peoples R China.;[Liu, Dongbo; Zhang, Zhixu] Hunan Agr Univ, Coll Hort, Changsha 410128, Hunan, Peoples R China.;[Qin, Dan] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.;[Guo, Xin] Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Hunan, Peoples R China.;[Lin, Haiyan] Natl Res Ctr Engn Technol Utilizat Ingredients Bot, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Guo, X ] C;Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Hunan, Peoples R China.
关键词:
Adsorption;Carbon dots;Pb(II);Starch
摘要:
The adsorption removal of lead (Pb) ions has become a crucial area of research due to the potential health hazards associated with Pb contamination. Developing cost-effective adsorbents for the removal of Pb(II) ions is significantly important. Hence, a novel fluorescent starch-based hydrogel (FSH) using starch (ST), cellulose nanofibrils (CN), and carbon dots (CD) was fabricated for simultaneous adsorption and detection of Pb(II). A comprehensive characterization of FSH, including its morphological features, chemical composition, and fluorescence characteristics, was conducted. Notably, FSH exhibited a maximum theoretical adsorption capacity of 265.9mg/g, which was 13.0 times higher than that of pure ST. Moreover, FSH was employed as a fluorescent sensor for Pb(II) determination, achieving a limit of detection (LOD) of 0.06μg/L. An analysis was further performed to investigate the adsorption and detection mechanisms of Pb(II) utilizing FSH. This study provides valuable insights into the production of a novel cost-effective ST-based adsorbent for the removal of Pb(II) ions.
通讯机构:
[Deng, T ] C;[Li, JS ] H;Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.;Cent South Univ Forestry & Technol, Sch Sci, Inst Appl Chem, Changsha 410004, Hunan, Peoples R China.
摘要:
A novel AIEgen molecular probe (N-3QL) with typical AIE effects, good biocompatibility, lysosome targeting, pH activation, excellent photostability, and high brightness was synthesized using two simple synthetic steps. Spectroscopic and cytotoxicity experiments indicate that N-3QL can not only be used for the dynamic monitoring of cancer cell lysosomes, but also for photodynamic therapy (PDT) ablation of cancer cells. A pH-activated AIE molecular probe (N-3QL) was synthesized for the purpose of lysosome fluorescence tracking and PDT ablation of cancer cells.
作者机构:
[Ning Zhang] College of Science, Central South University of Forestry and Technology, Changsha 410004, P. R. China;[Dandan Gao; Ziyu Zhuang] Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, P. R. China;Key Lab of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Chinese Academy of Sciences, Xining 810008, P. R. China;College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China;[Dongdong Li] Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, P. R. China<&wdkj&>Key Lab of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Chinese Academy of Sciences, Xining 810008, P. R. China
通讯机构:
[Dongdong Li] Q;Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining 810008, P. R. China<&wdkj&>Key Lab of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Chinese Academy of Sciences, Xining 810008, P. R. China
摘要:
Lithium aluminum layered double hydroxide chlorides (LADH-Cl) have been widely used for lithium extraction from brine. Elevation of the performances of LADH-Cl sorbents urgently requires knowledge of the composition-structure-property relationship of LADH-Cl in lithium extraction applications, but these are still unclear. Herein, combining the phase equilibrium experiments, advanced solid characterization methods, and theoretical calculations, we constructed a cyclic work diagram of LADH-Cl for lithium capture from aqueous solution, where the reversible (de)hydration and (de)intercalation induced phase evolution of LADH-Cl dominates the apparent lithium "adsorption-desorption" behavior. It is found that the real active ingredient in LADH-Cl type lithium sorbents is a dihydrated LADH-Cl with an Al:Li molar ratio varying from 2 to 3. This reversible process indicates an ultimate reversible lithium (de)intercalation capacity of ∼10 mg of Li per g of LADH-Cl. Excessive lithium deintercalation results in the phase structure collapse of dihydrated LADH-Cl to form gibbsite. When interacting with a concentrated LiCl aqueous solution, gibbsite is easily converted into lithium saturated intercalated LADH-Cl phases. By further hydration with a diluted LiCl aqueous solution, this phase again converts to the active dihydrated LADH-Cl. In the whole cyclic progress, lithium ions thermodynamically favor staying in the Al-OH octahedral cavities, but the (de)intercalation of lithium has kinetic factors deriving from the variation of the Al-OH hydroxyl orientation. The present results provide fundamental knowledge for the rational design and application of LADH-Cl type lithium sorbents.
摘要:
Sb-based materials exhibit considerable potential for sodium-ion storage owing to their high theoretical capacities. However, the bulk properties of Sb-based materials always result in poor cycling and rate performances. To overcome these issues, pyridine-regulated Sb@InSbS3 ultrafine nanoplates loaded on reduced graphene oxides (Sb@InSbS3@rGO) were designed and synthesized. During the synthesis process, pyridine was initially adopted to coordinate with In3+, and uniformly dispersed In2S3 ultrafine nanoplates on reduced graphene oxide were generated after sulfidation. Next, partial In3+ was exchanged with Sb3+, and Sb@InSbS3@rGO was obtained by using the subsequent annealing method. The unique structure of Sb@InSbS3@rGO effectively shortened the transfer path of sodium ions and electrons and provided a high pseudocapacitance. As the anode in sodium-ion batteries, the Sb@InSbS3@rGO electrode demonstrated a significantly higher reversible capacity, better stability (445 mAh<middle dot>g(-1) at 0.1 A<middle dot>g(-1) after 200 cycles and 212 mAh<middle dot>g(-1) at 2 A<middle dot>g(-1) after 1200 cycles), and superior rate (210 mAh<middle dot>g(-1) at 6.4 A<middle dot>g(-1)) than the electrode without pyridine (355 mAh<middle dot>g(-1) at 0.1 A<middle dot>g(-1) after 55 cycles and 109 mAh<middle dot>g(-1) at 2 A<middle dot>g(-1) after 770 cycles). Furthermore, full cells were assembled by using the Sb@InSbS3@rGO as anode and Na3V2(PO4)(3) as cathode, which demonstrated good cycling and rate performances and exhibited promising application prospects. These results indicate that adjusting the microstructure of electrode materials through coordination balance is A<middle dot>good strategy for obtaining high-capacity, high-rate, and long-cycle sodium storage performances.
作者:
Li Ji;Song Sheng;Fangyuan Shen;Lili Yang;Shizhi Wen;...
期刊:
CATENA,2024年237:107816 ISSN:0341-8162
通讯作者:
Li Ji<&wdkj&>Xu Wang<&wdkj&>Lixue Yang
作者机构:
[Song Sheng; Lili Yang; Shizhi Wen; Gongxiu He] School of Forestry, Central South University of Forestry and Technology, 410004 Changsha, PR China;[Fangyuan Shen; Lixue Yang] Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, School of Forestry, Northeast Forestry University, 150040 Harbin, PR China;Hunan Key Laboratory for Conservation and Utilization of Biological Resources in the Nanyue Mountainous Region, Hengyang Normal University, 421008 Hengyang, PR China;School of Life Science, Hengyang Normal University, 421008 Hengyang, PR China;[Xu Wang] Research Institute of Tropical Forestry, Chinese Academy of Forestry, 510520 Guangzhou, PR China
通讯机构:
[Li Ji] S;[Xu Wang] R;[Lixue Yang] K;Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, School of Forestry, Northeast Forestry University, 150040 Harbin, PR China<&wdkj&>Research Institute of Tropical Forestry, Chinese Academy of Forestry, 510520 Guangzhou, PR China<&wdkj&>School of Forestry, Central South University of Forestry and Technology, 410004 Changsha, PR China<&wdkj&>Key Laboratory of Sustainable Forest Ecosystem Management-Ministry of Education, School of Forestry, Northeast Forestry University, 150040 Harbin, PR China
摘要:
Soil bacteria, as integral components of the soil microbial community, play pivotal roles in biogeochemical cycles and ecosystem functions in boreal forests. The altitudinal patterns of soil bacteria have been widely reported, but their community assembly is uncertain. Here, we investigated the soil bacterial community attributes (diversity, taxonomic and functional composition, and bacterial interactions) and ecological processes associated with community assembly on Mt. Oakley in the northern Greater Khingan Mountains via Illumina MiSeq sequencing and functional annotation tools. The alpha diversity indices of the soil bacteria exhibited a progressively decreasing trend with increasing altitude across seasons. The relative abundance of the dominant bacterial taxa was more sensitive to altitude than to season. More complex (more nodes and links) bacterial interactions were detected at the lowest and highest altitudinal sites, as well as in September. The variations in the taxonomic and functional compositions of the soil bacteria induced by altitude were mainly driven by the variations in soil pH and extracellular enzyme activities. Stochastic (dispersal limitation and drift) processes largely controlled the soil bacterial community assemblages across spatiotemporal scales. The community assemblages of soil bacteria were affected by altitude-induced changes in the taxonomic composition and functional groups. Collectively, our results have significant implications for understanding bacterial biogeography and community assembly mechanisms along altitudinal gradients in boreal forest ecosystems.
作者机构:
[Mengping Luo; Caihong Chen; Fen Xiao; Jing Yi; Wanpeng Zhou; Jiyun She] College of Forestry, Central South University of Forestry & Technology, Changsha 410004, China
通讯机构:
[Jiyun She] C;College of Forestry, Central South University of Forestry & Technology, Changsha 410004, China
摘要:
The distribution of species is mostly influenced by climate synergistic effects and land use. The prediction of endangered species is dependent on fine-scale environmental features, especially in forests. The capture of fine-scale suitable habitats is bounded by low spatial resolution and coarse categorization. In this study, we improved the land use information and forest spatial detail through high forest thematic resolution land use data. To understand the relative influence of environmental factors, suitable habitat models for Chinese endangered tree species (Firmiana danxiaensis) under three climate and high forest thematic resolution land use conditions was constructed. We also assess F. danxiaensis 's response to climate and land use, and differential performance in land use on the suitable habitat. The area of suitable habitat for F. danxiaensis grows slowly under the SSP1-2.6 (shared social pathway scenario) scenario, decreases by 21.33% from the present to 2090 under the SSP2-4.5 scenario, and expands significantly under the SSP5-8.5 scenario. We conclude that high forest thematic resolution land use is beneficial in capturing species' requirements for specific habitats and especially necessary in predicting endangered species. At the same time, the distribution of suitable habitats for species is primarily driven by climate, and limited their development by land use. The study shows that the synthetic effects of climate and land use change on F. danxiaensis are positive, with a marked trend toward the northeast. As a consequence, some endangered species are able to benefit from future SSPs scenarios, in particular they respond more strongly to the SSP5-8.5 scenario than to the other scenarios. Assessing the role of changes in the climate and high forest thematic resolution land use on F. danxiaensis will help promote sustainable land use management and contribute to the conservation policy for Chinese endangered species.
摘要:
Aesthetic expectations often constitute the primary focus in marketing nature-based tourist destinations. However, academic research has insufficiently explored the disparity between tourists' aesthetic expectations and the actual aesthetic quality maintenance in shaping satisfaction. Employing the Expectation Confirmation Theory, this study utilized structural equation modeling techniques to analyze survey data (n = 446). It proposed and tested an Aesthetic Expectation Confirmation Model to examine the relationship between aesthetic expectations, experiential qualities, and tourist satisfaction in the Zhangjiajie National Forest Park. The empirical findings show that aesthetic expectations have a direct, negative impact on satisfaction, while aesthetic expectation confirmation has a positive direct impact on satisfaction. Moreover, aesthetic expectation confirmation also plays a mediating role in the influence of aesthetic expectations and experiential quality on satisfaction. Specifically, aesthetic expectations indirectly impact satisfaction negatively through aesthetic expectation confirmation, whereas aesthetic experiential qualities have a positive, indirect impact on satisfaction through the same process. These findings offer theoretical contributions to the literature on forest recreation aesthetics and hold practical significance for the planning and management of destination aesthetics.
摘要:
In eukaryotic cells, epigenetic modifications of DNA and histone play an important role in the regulation of gene expression. ROXY19 is a member of the plant specific CC-type glutaredoxins (GRXs). We found previously that ROXY19, by association with the TOPLESS/TOPLESS-related (TPL/TPR) family, strongly repressed a subset of genes which were positively regulated by the class II TGA factors. Arabidopsis plants ectopic expressing ROXY19 (ROXY19OE) were hypersensitive to xenobiotic chemicals due to the silencing of detoxification pathway genes. Here, we confirmed in vivo the interaction between ROXY19 and TPL. In order to understand the molecular mechanism underlying ROXY19-TPL module mediated gene repression, DNA methylation and histone deacetylation inhibitors were applied to assess the involvement of epigenetic modifications in the silencing of detoxification pathway genes in ROXY19OE plants. Promoter regions of some ROXY19 repressed genes were not methylated in wild-type/Col-0, and the methylation status were not altered in ROXY19OE. Furthermore, we investigated the role of epigenetic modifications in the antagonistic interplay between ethylene/jasmonic acid (ET/JA) and salicylic acid (SA) signaling pathways, which were supposed to be regulated by ROXY19.
作者机构:
[Li, Zhi; Zhou, Daixi; Zhu, Mingshan] Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511443, P. R. China;[Hu, Xinjiang] College of Environmental Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, P. R. China;[Chen, Li] Department of General Practice, First Medical Center, Chinese PLA General Hospital, Beijing, 100853, P. R. China
关键词:
advanced oxidation process;persulfate;reactive oxygen species;single atom catalysts;substance
摘要:
In this review, SACs with different metal species and substrates are summarized to investigate the metal−support interaction effects on the persulfate oxidation reaction for water treatments. Abstract With maximum utilization of active metal sites, more and more researchers have reported using single atom catalysts (SACs) to activate persulfate (PS) for organic pollutants removal. In SACs, single metal atoms (Fe, Co, Cu, Mn, etc.) and different substrates (porous carbon, biochar, graphene oxide, carbon nitride, MOF, MoS2, and others) are the basic structural. Metal single atoms, substances, and connected chemical bonds all have a great influence on the electronic structures that directly affect the activation process of PS and degradation efficiency to organic pollutants. However, there are few relevant reviews about the interaction between metal single atoms and substances during PS activation process. In this review, the SACs with different metal species and substrates are summarized to investigate the metal−support interaction and evaluate their effects on PS oxidation reaction process. Furthermore, how metal atoms and substrates affect the reactive species and degradation pathways are also discussed. Finally, the challenges and prospects of SACs in PS‐AOPs are proposed.
作者机构:
[Luo, Kun; Xie, Can; Liu, Ting; Yuan, Xiaomin] College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China;[Zhou, Liyi] College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China. Electronic address: zhouly0817@163.com
通讯机构:
[Zhou, Liyi] C;College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China. Electronic address:
关键词:
Cadmium ion;Enrichment and removal;Fluorescent probe;Functionalized glass slide
摘要:
Cadmium (Cd) is a widespread and highly toxic environmental pollutant, seriously threatening animal and plant growth. Therefore, monitoring and employing robust tools to enrich and remove Cd from the environment is a major challenge. In this work, by conjugating a fluorescent indicator (CCP) with a functionalized glass slide, a special composite material (CCPB) was constructed to enrich, remove, and monitor Cd(2+) in water rapidly. Then Cd(2+) could be effectively eluted by immersing the Cd-enriched CCPB in an ethylenediaminetetraacetic acid (EDTA) solution. With this, the CCPB was continuously reused. Its recovery of Cd(2+)was above and below 100 % after multiple uses by flame atomic absorption spectrometry (FAAS), which was excellent for practical use in enriching and removing Cd(2+) in real aqueous samples. Therefore, CCPB is an ideal material for monitoring, enriching, and removing Cd(2+) in wastewater, providing a robust tool for future practical applications of Cd enrichment and removal in the environment.
期刊:
Journal of Hazardous Materials,2024年466:133653 ISSN:0304-3894
作者机构:
[Luo, Kun; Xie, Can; Yuan, Xiaomin; Liu, Ting] Central South University of Forestry and Technology, Changsha, Hunan 410004, China;[Zhou, Liyi] Central South University of Forestry and Technology, Changsha, Hunan 410004, China. Electronic address: zhouly0817@163.com
摘要:
Cadmium-contaminated water and food are seriously hazardous to the human health, especially liver injury. To understand the entanglement relationship between cadmium ion (Cd(2+))-induced liver injury and the biomarker sulfur dioxide (SO(2)), a reliable bioanalytical tool is urgently needed, detecting SO(2) to diagnose and evaluate the extent of liver injury in vivo. Herein, based on the Förster resonance energy transfer (FRET) mechanism, a novel SO(2)-tunable NIR ratiometric fluorescent probe (SMP) was developed, it was used to diagnose and treat liver injury induced by Cd(2+) in biosystems. Specifically, it was constructed by conjugating a NIR dicyanoisophorone with a NIR benzopyranate as the donor and acceptor, respectively, and the ratiometric response of SO(2)- regulated by the Michael addition reaction. In addition, SMP exhibits rapid reaction time (<15s), two well-resolved emission peaks (68nm) with less cross-talk between channels for high imaging resolution, superior selectivity, and low limit of detection (LOD=80.3nM) for SO(2) detection. Impressively, SMP has been successfully used for intracellular ratiometric imaging of Cd(2+)-induced SO(2) and diagnostic and therapeutic evaluation in liver injury mice models with satisfactory results. Therefore, SMP may provide a powerful molecular tool for revealing the occurrence and development relationship between SO(2) and Cd(2+)-induced liver injury. ENVIRONMENTAL IMPLICATION: Cadmium ions are one of the well-known toxic environmental pollutants, which are enriched in the human body through inhalation of cadmium-contaminated air or from the food chain, leading to damage in various organs, especially liver injury. Therefore, we developed a novel fluorescent probe that can specifically detect SO(2) in Cd(2+)-induced liver injury, which is critically important for the diagnosis and evaluation of Cd(2+)-induced liver injury diseases. The specific detection of SO(2) of this probe has been successfully demonstrated in live HepG2 cells and Cd(2+)-induced liver injury mice.
摘要:
The deterioration of food freshness and occurrence of spoilage is attributed to adverse external conditions during storage, leading to unnecessary waste and posing food safety concerns. Therefore, it is imperative to develop packaging that monitors and maintains food freshness. Intelligent and active packaging precisely meets these desired requirements. Intelligent packaging has the potential to offer real-time feedback on environmental changes within the packaging, providing valuable information about food quality and safety. On the other hand, active packaging represents a novel approach that incorporates active ingredients, such as antimicrobials into packages to enhance food quality. This review highlights recent advancements in dual -functional packaging utilizing various plant essential oils and pH -sensitive natural pigments. It explores different methods, with a focus on electrospinning, and also discusses existing challenges and future trends. This information aims to assist in the development of packaging systems, offering a new direction for the development of antibacterial and pHsensitive packaging.
摘要:
Octacosanol, a naturally occurring higher fatty alcohol, possessed numerous biological effects. However, octacosanol limited solubility in water due to its lipophilic nature and large structure, resulting in poor absorption and low bioavailability. To overcome this challenge, we developed a simple, environmentally friendly, and energy-efficient O/W nanoemulsion synthesis process. The nanoemulsion achieved an average droplet size of approximately 30nm, exhibited excellent dispersibility and stability at room temperature for 60days, and showcased robust storage properties insensitive to ambient temperature, pH, NaCl, and sucrose. Remarkably, the preparation process of the nanoemulsion maintained the biological activity of octacosanol while demonstrating significantly enhancing antioxidant activity compared to octacosanol suspension. Additionally, the nanoemulsion displayed negligible cytotoxic effects on Caco-2 cells. Significantly, the octacosanol nanoemulsion exhibited a 5.4-fold enhancement in transmembrane transport efficiency when compared to the suspension in Caco-2 cell monolayers. Additionally, in an in vivo experiment, there was a notable 2.9-fold increase in rat intestinal absorption. These findings could provide valuable insights into the development of octacosanol nanoemulsion, supporting its future applications and paving the way for the design of stable nanoemulsion systems for other lipophilic and sparingly soluble substances.
作者机构:
[Dandan Qin; Zuomin Hu; Feiyan Yang; Tiantian Xie; Qi Wu; Han Lu; Weidan Guo; Xiuxiu Wu; Shuguo Sun; Feijun Luo] Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China
通讯机构:
[Shuguo Sun; Feijun Luo] H;Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, 410004, China
摘要:
Myocardial ischemia-reperfusion (MI/R) not only causes cardiac damage, but also causes severe renal damage. T8 is the 8th peptide identified by peptiomics in digested yak milk dregs and our previous studies showed that T8 had strong antioxidant activity. This study evaluated the protective effects and molecular mechanisms of MI/R-induced kidney injury in rats. Our results indicated that peptide T8 could increase ejection fraction (EF) and shortened fraction (FS), and degraded ST segment elevation, which ameliorated cardiac function in the MI/R rats. Peptide T8 could increase activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and decreased the contents of malondialdehyde (MDA), serum creatinine (Scr) and blood urea nitrogen (BUN), which could ameliorate renal insufficiency. Peptide T8 and kidney injury-related targets in the MI/R-damaged rats were obtained from network pharmacology analysis. KEGG analysis revealed that T8 might affect 54 signaling pathways and 13 key targets were obtained by PPI network analysis. The binding affinity of peptide T8 to Keap1 was found to be the strongest by molecular docking analysis. In the H2O2-induced HEK293 cell model, peptide T8 decreased reactive oxygen species (ROS) content and changed the expression ratio of Bcl-2 and Bax, thereby inhibiting mitochondria-dependent apoptosis. Further studies indicated that T8 could regulate Nrf2 pathway and downstream target genes such as NQO1, which could reduce oxidative stress-induced damage. These results suggest that peptide T 8 can exert renal protection via regulating Nrf2 pathway and apoptosis-related genes.
摘要:
The function of the pith ring and cortex in biological and fluid exchanges with the surrounding environment implies a natural intelligence. Their ingenious structure enables bamboo to thrive and impacts its processing and utilization. As drying is an essential step in bamboo product manufacturing, in this study, the effects of the pith ring and cortex on the water loss, deformation, and cracking of bamboo at the macroscopic, tissue, and cellular levels were investigated. Our study revealed a previously unknown mechanism of bamboo drying deformation. The cortex significantly affected the rate of water loss, whereas the pith ring did not significantly reduce the drying rate. Three deformation mechanisms originating from the pith ring were identified: the cell structure and orientation, self-flattening during drying, and excellent bending performance in the chord direction. These pith ring characteristics led to a larger radius of the bamboo splits during drying. These findings expand our understanding of the natural intelligence of the inner and outer layers of bamboo and provide important insights into bamboo drying, deformation, cracking, bionics, and composite material manufacturing.