Enhancing solubility and bioavailability of octacosanol: Development of a green O/W nanoemulsion synthesis process

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期刊论文

作者：

Jia, Mingxi;Bai, Weidong;Deng, Jing;Li, Wen;Lin, Qinlu;...

通讯作者：

Li, W

作者机构：

[Luo, Feijun; Zhong, Feifei; Deng, Jing; Li, Wen; Jia, Mingxi; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & Byproduct Deep Proc, Hunan Prov Key Lab Edible Forestry Resources Safet, Changsha 410004, Hunan, Peoples R China.

[Jia, Mingxi; Bai, Weidong] Zhongkai Univ Agr & Engn, Coll Light Ind & Food Sci, Guangzhou 510225, Guangdong, Peoples R China.

[Li, Wen; Jia, Mingxi; Lin, Qinlu] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat, Nanjing 210023, Jiangsu, Peoples R China.

[Li, Wen; Lin, Qinlu] Hunan Prov Engn Technol Res Ctr Seasonings Green M, Changsha 410004, Peoples R China.

[Zhong, Feifei] Changsha Inst Food & Drug Control, Changsha 410016, Hunan, Peoples R China.

通讯机构：

[Li, W ] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & Byproduct Deep Proc, Hunan Prov Key Lab Edible Forestry Resources Safet, Changsha 410004, Hunan, Peoples R China.

Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat, Nanjing 210023, Jiangsu, Peoples R China.

Hunan Prov Engn Technol Res Ctr Seasonings Green M, Changsha 410004, Peoples R China.

语种：

英文

关键词：

Bioavailability;Cytotoxicity;Octacosanol nanoemulsion;Solubility;Stability

期刊：

International Journal of Pharmaceutics

ISSN：

0378-5173

年：

2024

卷：

651

页码：

123726

DOI：

10.1016/j.ijpharm.2023.123726

基金类别：

Scientific Research Fund of Hunan Provincial Education Department [21A0161]; Key program of Hunan Provincial Department of science and technology [2020WK2020]; Natural Science Foundation of Hunan Province of China [2020JJ4278]; Central South University of Forestry and Technology Introduced Talent Research Startup Fund [2021YJ034, 2021YJ014]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Octacosanol, a naturally occurring higher fatty alcohol, possessed numerous biological effects. However, octacosanol limited solubility in water due to its lipophilic nature and large structure, resulting in poor absorption and low bioavailability. To overcome this challenge, we developed a simple, environmentally friendly, and energy-efficient O/W nanoemulsion synthesis process. The nanoemulsion achieved an average droplet size of approximately 30nm, exhibited excellent dispersibility and stability at room temperature for 60days, and showcased robust storage properties insensitive to ambient ...

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Enhancing solubility and bioavailability of octacosanol: Development of a green O/W nanoemulsion synthesis process

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