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A novel pH-activated AIEgen probe for dynamic lysosome tracking and high-efficiency photodynamic therapy

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成果类型:
期刊论文
作者:
Hu, Yingcai;Yin, Sheng-Yan;Deng, Ting;Li, Jishan
通讯作者:
Li, JS;Deng, T
作者机构:
[Hu, Yingcai; Yin, Sheng-Yan; Li, Jishan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.
[Deng, Ting] Cent South Univ Forestry & Technol, Sch Sci, Inst Appl Chem, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Deng, T ] C
[Li, JS ] H
Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.
Cent South Univ Forestry & Technol, Sch Sci, Inst Appl Chem, Changsha 410004, Hunan, Peoples R China.
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2024
卷:
60
期:
22
页码:
3047-3050
基金类别:
National Natural Science Foundation of China#&#&#22274039#&#&#22376224
机构署名:
本校为通讯机构
院系归属:
理学院
摘要:
A novel AIEgen molecular probe (N-3QL) with typical AIE effects, good biocompatibility, lysosome targeting, pH activation, excellent photostability, and high brightness was synthesized using two simple synthetic steps. Spectroscopic and cytotoxicity experiments indicate that N-3QL can not only be used for the dynamic monitoring of cancer cell lysosomes, but also for ph...

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