摘要：
The purpose of this study was to improve the solubility of resveratrol (Res) by a self-microemulsifying drug-delivery system (SMEDDS). Through a solubility experiment, the pseudoternary phase diagram and ternary phase diagram were used to optimize the Res SMEDDS formula. The optimum formulation consisted of 5% IPM, 20% PEG400, and 65% Cremophor RH40. The water solubility, stability, in vitro release and antioxidant activity of the Res SMEDDS were characterized. The Res solubility in the SMEDDS was at least 1,000 times compared to that in water. The average droplet size of the microemulsion was 28.00+/-1.67 nm and uniform distribution. The Res SMEDDS should be stored at low temperature and in the dark to avoid light conditions. Res SMEDDS was able to improve the in vitro release rate of Res, and the in vitro release of Res from Res SMEDDS was significantly faster that of Res powder and unaffected by pH value of media. Antioxidant assays showed that antioxidant activities of Res in Res SMEDDS were unaffected compared to Res powder. Cytotoxicity study indicated that Res SMEDDS at the concentration of less than 100 muM was safe. These results demonstrated the potential use of Res SMEDDS for oral administration of Res.
作者机构：
[王玲芝; 旷春桃; 周军] School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, China;National Engineering Lab. for Applied Technology of Forestry & Ecology in South China, Changsha, 410004, China;[李湘洲] School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, China<&wdkj&>National Engineering Lab. for Applied Technology of Forestry & Ecology in South China, Changsha, 410004, China
摘要：
为了充分利用山桐子资源,采用单因素试验和 Box-Be-hnken 试验设计优化山桐子油的超临界 CO 2萃取工艺,运用气相色谱—质谱(GC—MS)分析山桐子油的脂肪酸组成。结果表明：超临界 CO 2萃取山桐子油的优化工艺条件为萃取时间147 min,萃取温度53℃,萃取压力24 MPa；在该条件下,山桐子油得率为(38.25±0.41)%。山桐子油得率和影响因素间的回归模型极显著(P=0.0009)。GC—MS 结果表明,山桐子油主要由不饱和脂肪酸组成,不饱和脂肪酸含量为81.33%,亚油酸含量为71.43%。山桐子油是一种优质的食用油资源,超临界 CO 2可以高效萃取山桐子油。
摘要：
The inclusion complex formation of curcumin with β-CD was studied by spectrophotometry,and the apparent formation constant for curcumin-β-CD complex was determined.The stiochiometric ratio of curcumin-β-CD complex was investigated by Job’s continuous variation methods.The results showed that a 1:1 complex between curcumin and β-CD was formed,and the apparent formation constants decreased with the increase of reaction temperature.The thermodynamic parameters,standard free energy (ΔG°),enthalpy (ΔH°) and entropy (ΔS°) for complex formation of curcumin with β-CD were calculated.The inclusion complex was confirmed by infrared spectrum (IR) and thermogravimetric analysis (TGA).
作者机构：
[旷春桃; 李湘洲; 薛海鹏; 邓楠; 王玲芝] College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, China
通讯机构：
College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, China
摘要：
Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification, isomerization, chlorination and esterification. The yields of curcumin derivatives c1-c4 were 80.5%, 83.7%, 81.2% and 85.4%, respectively. Their structures were confirmed by IR, 1H NMR and 13C NMR. The antioxidative and antibacterial activities of target compounds c1-c4 were evaluated. The IC50 values for scavenging of DPPH· were 164.14±0.82, 166. 98±0.66, 171.97±0.99 and 175.10±2.34 mg/L, respectively. Their antioxidative activity was lower than that of curcumin (36.22±0.22 mg/L). This proved the importance of phenolic OH. The target compounds c1-c4displayed high antibacterial activity, especially compound c4. The minimal inhibiting concentration(MIC) of c4 againstStaphylococcus aureus, Escherichia coli, Penicillium sp. and Aspergillus niger were 0.5, 0.5, 0.25 and 1.0 g/L, respectively. There is hope to obtain antibacterial candidates by curcumin modification with α, β-unsaturated carbonyl compounds.
作者机构：
[旷春桃; 李湘洲; 韩艳利; 王玲芝; 张杉林] College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, China
通讯机构：
College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, China
作者机构：
[旷春桃; 李湘洲; 韩艳利; 王玲芝; 张杉林] College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha;410004, China;[旷春桃; 李湘洲; 韩艳利; 王玲芝; 张杉林] 410004, China
通讯机构：
College of Material Science and Engineering, Central South University of Forestry and Technology, Changsha, China
