期刊论文

Synthesis of chalcone derivatives and their antibacterial and antioxidant activities

中文

中国科技论文

2095-2783

2013

8

9

862-864

10.3969/j.issn.2095-2783.2013.09.007

(20094321110001):高等学校博士学科点专项科研基金资助项目 (QJ2010003A):中南林业科技大学青年科学研究基金重点项目

本校为第一机构

以对甲氧基苯乙酮和苯甲醛衍生物为原料,采用0.1 g/mL的NaOH溶液为催化剂,经aldol缩合获得了3种查尔酮衍生物,采用1 H-NMR对其进行了结构表征.采用生长速率法测定了3种查尔酮衍生物的抗菌活性,以DPPH·的半清除率(IC50)表示抗氧化活性.结果表明:4 '-甲氧基查尔酮、4 '甲氧基4羟基查尔酮和4 '-甲氧基-4-羟基3-甲氧基查尔酮的收率分别为65.80％、30.30％和45.07％;4'-甲氧基-4-羟基查尔酮的抗菌活性最好,对真菌的抑制活性优于细菌;查尔酮衍生物具有一定的抗氧化活性.

Using 0.1g/mL NaOH solution as catalysis,three chalcone derivatives have been synthesized from 4-methoxyacetophenone and benzaldehyde derivatives by aldol condensation,and their structures have been confirmed by 1 H-NMR.Antibacterial activity of chalcone derivatives was determined by plate growth rate method,and IC50of DPPH·scavenging ratio was used to express their antioxidant activity.The results showed that the yields of 4′-methoxy chalcone,4′-methoxy-4-hydroxyl chalcone and 4′-methoxy-4-hydroxyl-3-methoxy chalcone were 65.80%,30.30% and...