期刊论文

Preparation of water-soluble resveratrol/HP-β-CD microcapsule by spray drying method

中文

食品与机械

1003-5788

2019

35

4

192-196

10.13652/j.issn.1003-5788.2019.04.035

“十三五”国家重点研发计划（编号:2016YFD0600805-04）；

本校为第一机构

利用羟丙基-β-环糊精(HP-β-CD)改善Res的水溶性,优化了喷雾干燥法制备Res/HP-β-CD微胶囊的工艺,采用UV、IR和SEM对Res/HP-β-CD微胶囊进行结构表征.结果表明,Res/HP-β-CD微胶囊的优化制备工艺为w Res︰w HP-β-CD 1︰5(g/g),搅拌温度30℃,进料流量2.1 mL/min,进风温度140℃,载药量15.18%,溶解度12.75 g/L.UV、IR和SEM结果表明,Res与HP-β-CD通过氢键、疏水作用力等作用力形成Res/HP-β-CD微胶囊,并且粒径减少,提高了Res的水溶性.

Hydroxypropyl-β-cyclodextrin(HP-β-CD)was used to improve water solubility of Res.The preparation conditions of Res/HP-β-CD microcapsule by spray drying method were optimized,and Res/HP-β-CD microcapsule was confirmed by UV,IR and SEM.The results showed that optimum preparation conditions of Res/HP-β-CD microcapsule were mass ratio of Res to HP-β-CD for 1:5,stirring at 30 ℃,feed flow rate for 2.1 mL/min and inlet-air temperature for 140 ℃.The rate of drug-loading and the solubility of Res were 15.18% and12.75 g/L,respectively,under the o...