期刊论文

Effect of aralia echinocaulis extract on glucocorticoid-induced osteoporosis in rats

中文

中国骨质疏松杂志

Chinese Journal of Osteoporosis

1006-7108

2016

22

7

872-876

10.3969/j.issn.1006-7108.2016.07.017

国家自然科学基金(81173361,81270051,81473451)；

本校为其他机构

目的本研究拟在验证刺老苞根皮提取物对糖皮质激素诱发的大鼠骨质疏松症的干预作用。方法90只SD大鼠(雌雄各半)随机分成6组,即(雌/雄)对照组、(雌/雄)模型组、(雌/雄)治疗组(刺老苞根皮提取物组),每组15只。其中模型组与治疗组采用连续注射地塞米松磷酸钠(DXM)造成继发性骨质疏松,而后直接灌胃刺老苞根皮提取物(20 mg /kg),观察其治疗作用。8周后,检测脂代谢指标[血清胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)含量]、骨代谢指标[骨钙素(BGP)、1, 25-(OH2D3)、骨矿物含量、骨密度值、骨力学参数]、激素指标[甲状旁腺(PTH)、睾酮(T)、雌二醇(E_2)、生长激素(GH)、黄体...

Obje ctive To study that effect of aralia echinocaulis extract on glucocorticoid-induced osteoporosis in rats. Me thods Ninety SD rats（ half males and half females） were divided into 6 groups,including control groups,model groups,and treatment groups. After establishment of dexamethasone-induced osteoporosis rat model,rats received aralia echinocaulis extract（ 20 mg / kg）daily. At end of 8 weeks,the levels of lipid metabolic parameters（ TC,HDL-C,and LDL-C）,bone metabolic parameters（ BGP,1,25-（ OH）2D3,bone mineral content,BMD,and bone m...