期刊论文

Li, Xiang-Zhou

英文

林产化学与工业

0253-2417

2014

34

5

67-72

10.3969/j.issn.0253-2417.2014.05.011

(20120460103):国家林业公益性行业科研专项 (QJ2010003A):中南林业科技大学青年科学研究基金重点项目 (20094321110001):高等学校博士学科点专项基金项目

本校为第一且通讯机构

Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification, isomerization, chlorination and esterification. The yields of curcumin derivatives c1-c4 were 80.5%, 83.7%, 81.2% and 85.4%, respectively. Their structures were confirmed by IR, 1H NMR and 13C NMR. The antioxidative and antibacterial activities of target compounds c1-c4 were evaluated. The IC50 values for scavenging of DPPH· were 164.14±0.82, 166. 98±0.66, 171.97±0.99 and 175.10±2.34 mg/L, respectively. Their antioxidative activity was lower th...

以姜黄素和马来酸酐为原料,经酯化、异构化、酰氯化和酯化合成了4个姜黄素衍生物。姜黄素衍生物c1~c4的收率分别为80.5%、83.7%、81.2%和85.4%,用IR,1 H NMR和13 C NMR确证了目标化合物的结构。并对c1~c4的抗氧化活性和抗菌活性进行了评价。结果表明,姜黄素衍生物 c1~c4清除 DPPH ·的 IC50分别为164.14±0．82、166.98±0.66、171.97±0.99和175.10±2.34 mg/L,它们的抗氧化活性均低于姜黄素(36.22±0.22 mg/L),姜黄素的酚羟基对抗氧化活性有重要影响。 c1~c4均具有良好的抗菌活性,其中化合物c4的抗菌活性最好, c4对金黄色葡萄球菌、大肠杆菌、青霉菌和黑曲霉菌的最小抑菌浓度(MIC)分别为0.5、...