作者机构：
[Yang, Xin] Cent South Univ Forestry & Technol, Bangor Coll, Changsha 410004, Peoples R China.;[Long, Jiangping] Cent South Univ Forestry & Technol, Sch Civil Engn, Changsha 410004, Peoples R China.
通讯机构：
[Xin Yang] B;Bangor College, Central South University of Forestry and Technology, Changsha 410004, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
collapse mode;upper bound theorem;support pressure;failure probability
摘要：
Based on the kinematics-based upper bound theorem and reliability theory, the stability of deep tunnel roofs in nonlinear Hoek-Brown media is investigated. The performance functions of rectangular and circular tunnels are proposed according to the roof collapse mode, respectively, with support pressure and pore water pressure being considered. With the proposed performance function of the rectangular tunnels, the first-order reliability method is utilized to perform reliability analysis. The rock strength parameters are regarded as random variables following the normal or lognormal distribution. To assess the validity of the obtained results, reliability indexes for different support pressure values are calculated and compared with solutions using the response surface method and Monte-Carlo simulation. The agreement shows that the first-order reliability method effectively evaluates the reliability index with the proposed performance function. Sensitivity analysis is performed to throw light on the significance of different random variables, and the impact of the variation coefficient on reliability indexes is discussed. For circular tunnels, MCS is utilized to evaluate the roof stability with the proposed performance function. The influences of the support pressure on the reliability index and the corresponding design points are investigated. The parametric study shows that the normal distribution of random variables has more influence on the failure probability than that of the lognormal distribution. However, the difference between the two distributions is small. sigma(t) is the major factor that influences the reliability index compared to the B and r(u). The supporting pressure for circular tunnels is smaller than that of rectangular tunnels when a target reliability index of 2.5 (failure probability equals 0.62%) is given.
摘要：
随着中国教育国际化进程不断加快,加强来华留学生创新创业能力培养已成为新时代发展的必然要求.在来华留学生创新创业能力现状分析的基础上,运用OBE(Outcome Based Education,成果导向教育)理念,从总体目标设定、课程体系选择、教学策略运用和教学评价体系的改进等方面研究了培养路径并构建了培养模式,为来华留学生创新创业能力培养提供了科学的理论指导,也为"后疫情"时代下中国打造教育国际化的品牌指明道路.
摘要：
Background: The dysfunction of immune system and inflammation contribute to the Parkinson's disease (PD) pathogenesis. Cytokines, oxidative stress, neurotoxin and metabolism associated enzymes participate in neuroinflammation in PD and the genes involved in them have been reported to be associated with the risk of PD. In our study, we performed a quantitative and causal analysis of the relationship between inflammatory genes and PD risk. Methods: Standard process was performed for quantitative analysis. Allele model (AM) was used as primary outcome analysis and dominant model (DM) and recessive model (RM) were applied to do the secondary analysis. Then, for those genes significantly associated with the risk of PD, we used the published GWAS summary statistics for Mendelian Randomization (MR) to test the causal analysis between them. Results: We included 36 variants in 18 genes for final pooled analysis. As a result, IL-6 rs1800795, TNF-alpha rs1799964, PON1 rs854560, CYP2D6 rs3892097, HLA-DRB rs660895, BST1 rs11931532, CCDC62 rs12817488 polymorphisms were associated with the risk of PD statistically with the ORs ranged from 0.66 to 3.19 while variants in IL-1 alpha, IL-1 beta, IL-10, MnSOD, NFE2L2, CYP2E1, NOS1, NAT2, ABCB1, HFE and MTHFR were not related to the risk of PD. Besides, we observed that increasing ADP-ribosyl cyclase (coded by BST1) had causal effect on higher PD risk (OR[95%CI] =1.16[1.10-1.22]) while PON1(coded by PON1) shown probably protective effect on PD risk (OR[95%CI] =0.81[0.66-0.99]). Conclusion: Several polymorphisms from inflammatory genes of IL-6, TNF-alpha, PON1, CYP2D6, HLA-DRB, BST1, CCDC62 were statistically associated with the susceptibility of PD, and with evidence of causal relationships for ADP-ribosyl cyclase and PON1 on PD risk, which may help understand the mechanisms and pathways underlying PD pathogenesis.
期刊：
Open Journal of Modern Linguistics,2023年13(2):341-354 ISSN：2164-2818
作者机构：
College of Foreign Languages, Central South University of Forestry and Technology, Changsha, China;Bangor College, Central South University of Forestry and Technology, Changsha, China
摘要：
Discover the global concern surrounding morphological awareness research. Explore the rise in publications, reference co-citation analysis, and emerging trends in this comprehensive review. Find future research directions here.
作者机构：
[Wang, Yaoyao; Kuang, Yuanpei] Hunan Agr Univ, Sch Econ, Changsha 410125, Peoples R China.;[Wang, Yaoyao] Cent South Univ Forestry & Technol, Bangor Coll, Changsha 410004, Peoples R China.
通讯机构：
[Yuanpei Kuang] S;School of Economics, Hunan Agriculture University, Changsha 410125, China<&wdkj&>Author to whom correspondence should be addressed.
关键词：
high-quality agricultural development;regional disparity;driving mechanism;spatio-temporal range improved entropy approach
摘要：
Based on China's new development philosophy and the connotation of high-quality agricultural development, this study constructed a six-dimensional comprehensive evaluation framework: innovation-effectiveness-sustainability-coordination-openness-sharing. The spatio-temporal-range-improved entropy approach and the Dagum Gini coefficient were applied to evaluate and analyze the level of regional disparities and the dynamic distribution characteristics of high-quality agricultural development in China in the period from 2010 to 2018. The result shows that the level of high-quality agricultural development in China has steadily improved in general, but there exist prominent structural problems. Concerning regional differences, it indicated a pattern dominated by the pattern of "high in the east and low in the west", mainly arising from the inter-regional disparity, with a gradual downward trend during the selected period. This study also comprehensively explored the four-dimensional driving mechanisms (production conditions, productivity, production relations, and production efficiency), and further examined the driving paths of various variables and regional heterogeneity using a panel Tobit model.
期刊：
Sleep and Breathing,2023年27(3):973-982 ISSN：1520-9512
通讯作者：
Yuan Zhang
作者机构：
[Yan, Wenjie; Yi, Minhan; Lin, Ruihan; Zhang, Yuan; Li, Jiaxin] Cent South Univ, Xiangya Hosp, Dept Resp Med, Changsha, Peoples R China.;[Yan, Wenjie; Lin, Ruihan; Zhang, Yuan; Li, Jiaxin] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.;[Yan, Wenjie; Lin, Ruihan; Li, Jiaxin] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China.;[Yi, Minhan] Cent South Univ, Sch Life Sci, Changsha, Hunan, Peoples R China.;[Huang, Zini] Cent South Univ Forestry & Technol, Bangor Coll, Changsha, Hunan, Peoples R China.
通讯机构：
[Yuan Zhang] D;Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China<&wdkj&>National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
