摘要：
Inflammation and immunity play a major role in the development of hypertension, and a potential correlation between host mucosal immunity and inflammatory response regulation. We explored the changes of intestinal mucosal microbiota in hypertensive rats induced by high-salt diet and the potential link between the intestinal mucosal microbiota and inflammation in rats. Therefore, we used PacBio (Pacific Bioscience) SMRT sequencing technology to determine the structure of intestinal mucosal microbiota, used enzyme-linked immunosorbent assay (ELISA) to determined the proinflammatory cytokines and hormones associated with hypertension in serum, and used histopathology methods to observe the kidney and vascular structure. We performed a potential association analysis between intestinal mucosal characteristic bacteria and significantly different blood cytokines in hypertensive rats induced by high-salt. The results showed that the kidney and vascular structures of hypertensive rats induced by high salt were damaged, the serum concentration of necrosis factor-alpha (TNF-alpha), angiotensin II (AngII), interleukin-6 (IL-6), and interleukin-8 (IL-8) were significantly increased (p < 0.05), and the coefficient of immune organ spleen was significantly changed (p < 0.05), but there was no significant change in serum lipids (p > 0.05). From the perspective of gut microbiota, high-salt diet leads to significant changes in intestinal mucosal microbiota. Bifidobacterium animalis subsp. and Brachybacterium paraconglomeratum were the dominant differential bacteria in intestinal mucosal, with the AUC (area under curve) value of Bifidobacterium animalis subsp. and Brachybacterium paraconglomeratum were 1 and 0.875 according to ROC (receiver operating characteristic) analysis. Correlation analysis showed that Bifidobacterium animalis subsp. was correlated with IL-6, IL-8, TNF-alpha, and Ang II. Based on our results, we can speculated that high salt diet mediated chronic low-grade inflammation through inhibited the growth of Bifidobacterium animalis subsp. in intestinal mucosa and caused end-organ damage, which leads to hypertension.
作者机构：
[Li, Hongli; Yuan, Haigen] West Yunnan University, Yunnan, Lincang;677000, China;[Wu, Yi] Central South University of Forestry & Technology, Hunan, Changsha;410004, China;[Li, Hongli; Yuan, Haigen] 677000, China
会议名称：
7th International Conference on Cyber Security and Information Engineering, ICCSIE 2022
期刊：
Separation and Purification Technology,2022年303:122237 ISSN：1383-5866
通讯作者：
Xiancheng Ma<&wdkj&>Qingding Wu<&wdkj&>Liqing Li
作者机构：
[Wu, Yi; Wu, Qingding; Ma, Xiancheng] Cent South Univ Forestry & Technol, Coll Mech & Elect Engn, Changsha 410083, Hunan, Peoples R China.;[Li, Liqing; Zeng, Zheng; Guo, Yang] Cent South Univ, Sch Energy Sci & Engn, Changsha 410083, Hunan, Peoples R China.;[Su, Rongkui] Cent South Univ Forestry & Technol, Coll Environm Sci & Engn, Changsha 410083, Hunan, Peoples R China.;[Yao, Xiaolong] Beijing Technol & Business Univ, Dept Environm Sci & Engn, 11 Fuchenglu, Beijing 100048, Peoples R China.;[Wang, Shaobin] Univ Adelaide, Sch Chem Engn & Adv Mat, 108 King William St, Adelaide, SA 5005, Australia.
通讯机构：
[Xiancheng Ma; Qingding Wu] C;[Liqing Li] S;College of Mechanical & Electrical Engineering, Central South University of Forestry and Technology, Changsha 410083, Hunan, China<&wdkj&>School of Energy Science and Engineering, Central South University, Changsha 410083, Hunan, China
关键词：
Porous carbon;Pore structure;Nitrogen and oxygen groups;Iodine capture
摘要：
The removal of radioactive iodine species during nuclear accidents and nuclear fuel reprocessing is crucial to nuclear safety, public health and environmental protection. Here, a series of nitrogen-doped porous carbon derived from benzimidazole (NBCs) with well-developed pore structure were prepared. During KOH activation, the potassium salt formed at 600-700 degrees C is mainly K2CO3 and K2O, and the pore size obtained is mainly microporous. With the temperature increases, the K2CO3 and K2O are converted to KOCN, which generates mesopores. NBCs were subsequently tested for gaseous iodine and solution iodine. The results show that NBC800-2 exhibits the highest iodine vapor adsorption capacity (7873 mg/g) at 75 celcius. Theoretical calculations and experimental data show that the iodine adsorption of NBCs for iodine vapor is mainly determined by pore structure, especially micropores and narrow mesoporous. The effect of nitrogen and oxygen doping on the adsorption capacity of gaseous iodine is limited. In the cyclohexane solution, the adsorption capacity of NBCs for iodine is mainly determined by micropores. In KI/H2O solution, the iodine adsorption mainly depends on mi-cropores and narrow mesopores, which is completely different from the result of iodine adsorption in cyclo-hexane. This is mainly due to the fact that I3- has a larger diameter than I2, and the adsorption energy of I3- (82.8 kJ/mol) on the carbon surface is higher than that of I2 (58.1 kJ /mol). Moreover, Langmuir model can better describe the adsorption process of iodine in cyclohexane and KI/H2O solution than Freundlich model, which proves that the process is mainly monolayer formation. This study provides insights for the further design and development of adsorbents for iodine capture from nuclear waste and nuclear accidents.
期刊：
IOP Conference Series: Earth and Environmental Science,2020年440(4):042003 ISSN：1755-1307
通讯作者：
She, Jiyun
作者机构：
[Li, Changqing; Wu, Yi; She, Jiyun] Cent South Univ Forestry & Technol, Coll Forestry, Changsha 410000, Peoples R China.;[Lu, Yu] Natl Forestry & Grassland Adm, Cent South Inventory & Planning Inst, Changsha 410014, Hunan, Peoples R China.
通讯机构：
[She, Jiyun] C;Cent South Univ Forestry & Technol, Coll Forestry, Changsha 410000, Peoples R China.
会议名称：
5th International Conference on Environmental Science and Material Application (ESMA)
会议时间：
DEC 15-16, 2019
会议地点：
Xian, PEOPLES R CHINA
会议主办单位：
[Li, Changqing;She, Jiyun;Wu, Yi] Cent South Univ Forestry & Technol, Coll Forestry, Changsha 410000, Peoples R China.^[Lu, Yu] Natl Forestry & Grassland Adm, Cent South Inventory & Planning Inst, Changsha 410014, Hunan, Peoples R China.
会议论文集名称：
IOP Conference Series-Earth and Environmental Science
摘要：
This paper took Changjiang County as the study district. The selection of ecological source were analyzed by using GIS technology, granularity inverse method and principal component analysis. The result of the granularity inverse method and principal component analysis was that the optimal landscape composition structure of Changjiang County had a particle size of 600 m; there were 14 ecological sources aggregately, and 23 pieces of ecological landscape patches needed to increase newly. Besides, the distribution trend of ecological source was characterized by a large quantity but small scale in the central section and small quantity but large scale in the southeast and northwest, which was mainly influenced by human disturbance.
