To clarify the influence of food internal and external factors on the antimicrobial activity of metal antimicrobial peptide SIF4, adopting Staphylococcus aureus as the indicative bacteria, the effects of temperature, pH, metal cation, protease, repeated freeze-thaw cycles and chemical reagent on antimicrobial activity were investigated, and its biocompatibility was also studied. Results showed that SIF4 had good thermal-stability and pH-stability, it remained (92. 68 ± 0. 40)% anti-microbial activity after 121 ℃ treatment, and more than (99. ...