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Low Basal CB2R in Dopamine Neurons and Microglia Influences Cannabinoid Tetrad Effects

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成果类型:
期刊论文
作者:
Liu, Qing-Rong*;Canseco-Alba, Ana;Liang, Ying;Ishiguro, Hiroki;Onaivi, Emmanuel S.*
通讯作者:
Liu, Qing-Rong;Onaivi, Emmanuel S.
作者机构:
[Liu, Qing-Rong] NIA, Lab Clin Invest, Baltimore, MD 21224 USA.
[Canseco-Alba, Ana; Onaivi, Emmanuel S.] William Paterson Univ, Dept Biol, Wayne, NJ 07470 USA.
[Liang, Ying] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Hunan, Peoples R China.
[Ishiguro, Hiroki] Univ Yamanashi, Grad Sch Med Sci, Dept Neuropsychiat, Chuo Ku, Yamanashi 4093898, Japan.
[Canseco-Alba, Ana] Inst Nacl Neurol & Neurocirugia INNN, Direcc Invest, Lab Invest Adicc, Mexico City 14269, DF, Mexico.
通讯机构:
[Liu, Qing-Rong] N
[Onaivi, Emmanuel S.] W
NIA, Lab Clin Invest, Baltimore, MD 21224 USA.
William Paterson Univ, Dept Biol, Wayne, NJ 07470 USA.
语种:
英文
关键词:
2,3 dihydro 5 methyl 3 (morpholinomethyl) 6 (1 naphthoyl)pyrrolo[1,2,3 de][1,4]benzoxazine;cannabinoid;cannabinoid 1 receptor;cannabinoid 1 receptor agonist;cannabinoid 2 receptor;collagenase;messenger RNA;methamphetamine;cannabinoid;cannabinoid 1 receptor;cannabinoid 2 receptor;CNR1 protein, mouse;Cnr2 protein, mouse;alcohol consumption;alternative RNA splicing;analgesia;animal cell;animal experiment;animal model;animal tissue;antinociception;Article;binding site;brain cell;brain cortex;brain region;catalepsy;controlled study;dopaminergic nerve cell;exon;fluorescence activated cell sorting;fluorescence intensity;high-sucrose diet;hypothermia;immobility;in situ hybridization;in vivo study;liver;liver cell;liver perfusion;LoxP site;male;microglia;mouse;nociception;nonhuman;place preference;protein expression;RNA isolation;spleen;tetrad test;thalamus;thalamus lateral nucleus;thalamus nucleus;translation initiation;animal;animal behavior;C57BL mouse;dopaminergic nerve cell;drug effect;genetics;knockout mouse;metabolism;microglia;physiology;rat;Sprague Dawley rat;Animals;Behavior, Animal;Cannabinoids;Dopaminergic Neurons;Male;Mice;Mice, Inbred C57BL;Mice, Knockout;Microglia;Rats;Rats, Sprague-Dawley;Receptor, Cannabinoid, CB1;Receptor, Cannabinoid, CB2
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2020
卷:
21
期:
24
页码:
1-20
基金类别:
Funding: Research by Q.-R.L. is supported by the Intramural Research Program of NIA-NIH. Y.L. is supported by the College of Food Science and Engineering, Central South University of Forestry and Technology, China. Work in the E.S.O. laboratory is supported by William Paterson University ART, the Dean—CoSH funds that support the Animal laboratory, and NIAAA-NIH grant AA027909. Acknowledgments: Q.-R.L. acknowledges research support by the Intramural Research Program of NIA-NIH and technical support of Sudeep Gautam for hepatocyte isolation. H.I. acknowledges support by University of Yamanashi, Japan, E.S.O. acknowledges support as a Guest Researcher at NIDA-NIH Intramural Research Program. E.S.O. also acknowledges Venkat Sharma, the Dean CoSH at William Paterson University, for funds to support student workers. We are indebted to Marizel Mina, our Animal laboratory technician. Research by Q.-R.L. is supported by the Intramural Research Program of NIA-NIH. Y.L. is supported by the College of Food Science and Engineering, Central South University of Forestry and Technology, China. Work in the E.S.O. laboratory is supported by William Paterson University ART, the Dean?CoSH funds that support the Animal laboratory, and NIAAA-NIH grant AA027909. Acknowledgments: Q.-R.L. acknowledges research support by the Intramural Research Program of NIA-NIH and technical support of Sudeep Gautam for hepatocyte isolation. H.I. acknowledges support by University of Yamanashi, Japan, E.S.O. acknowledges support as a Guest Researcher at NIDA-NIH Intramural Research Program. E.S.O. also acknowledges Venkat Sharma, the Dean CoSH at William Paterson University, for funds to support student workers. We are indebted to Marizel Mina, our Animal laboratory technician.
机构署名:
本校为其他机构
院系归属:
食品科学与工程学院
摘要:
There are two well-characterized cannabinoid receptors (CB1R and CB2R and other candidates): the central nervous system (CNS) enriched CB1R and peripheral tissue enriched CB2R with a wide dynamic range of expression levels in different cell types of human tissues. Hepatocytes and neurons express low baseline CB1R and CB2R, respectively, and their cell-type-specific functions are not well defined. Here we report inducible expression of CB1R in the liver by high-fat and high sugar diet and CB2R in cortical neurons by methamphetamine. While there ...

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