Rice Bioactive Peptide Binding with TLR4 to Overcome H2O2-Induced Injury in Human Umbilical Vein Endothelial Cells through NF-κB Signaling

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成果类型：

期刊论文

作者：

Liang, Ying;Lin, Qinlu*;Huang, Ping;Wang, Yugian;Li, Jiajia;...

通讯作者：

Lin, Qinlu

作者机构：

[Huang, Ping; Li, Jiajia; Cao, Jianzhong; Wang, Yugian; Zhang, Lin; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Rice & Byprod Deep Proc, Mol Nutr Branch, Changsha 410004, Hunan, Peoples R China.

[Huang, Ping; Li, Jiajia; Cao, Jianzhong; Wang, Yugian; Zhang, Lin; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Lin, Qinlu] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Antioxidants;Bins;Cell death;Cells;Cytology;Endothelial cells;Peptides;Proteins;Bioactive peptides;Cardio-vascular disease;Human umbilical vein endothelial cells;HUVECs;Molecular mechanism;Protective function;Reactive oxygen species;Toll-like receptor 4;Cell signaling;caspase 3;hydrogen peroxide;immunoglobulin enhancer binding protein;peptide;plant extract;toll like receptor 4;apoptosis;cardiovascular disease;chemistry;drug effects;genetics;human;metabolism;Oryza;oxidative stress;pathophysiology;signal transduction;umbilical vein endothelial cell;Apoptosis;Cardiovascular Diseases;Caspase 3;Human Umbilical Vein Endothelial Cells;Humans;Hydrogen Peroxide;NF-kappa B;Oryza;Oxidative Stress;Peptides;Plant Extracts;Signal Transduction;Toll-Like Receptor 4

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2018

卷：

期：

页码：

440-448

DOI：

10.1021/acs.jafc.7b04036

基金类别：

This project was financially supported by the National Natural Science Foundation of China (No. 31201348/31571874) Hunan Youth Excellent Talents Supporting Program (No. 2016RS3033) Natural Science Foundation of Hunan Province (No. 2017JJ2410), Construction Project of Graduate textbook from Central South University of Forestry and Technology (No.2015JC03), Grain-oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province. *E-mail: linql0403@126.com. Tel.: +86-731-85623096. Fax: +86-731-85623038 (Q.L.). Address: College of Food Science and Engineering, Central South University of Forestry and Technology, No. 498 Shaoshan South Road, Changsha 410004, Hunan, China. ORCID Ying Liang: 0000-0002-6216-4743 Qinlu Lin: 0000-0002-5322-3916 Funding This project was financially supported by the National Natural Science Foundation of China (No. 31201348/31571874), Hunan Youth Excellent Talents Supporting Program (No. 2016RS3033), Natural Science Foundation of Hunan Province (No. 2017JJ2410), Construction Project of Graduate textbook from Central South University of Forestry and Technology (No.2015JC03), Grain-oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province. Notes The authors declare no competing financial interest.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Reactive oxygen species-induced vessel endothelium injury is crucial in cardiovascular diseases progression. Rice-derived bran bioactive peptides (RBAP) might exert antioxidant effect through unknown mechanisms. Herein, we validated the antioxidant effect and mechanism of RBAP on H2O2-induced oxidative injury in human umbilical vein endothelial cells (HUVECs). Here, HUVECs were treated with RBAP under H2O2 stimulation; the effects of RBAP on HUVECs oxidative injury were evaluated. H2O2 injury-induced cell morphology changes were ameliorated by ...

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Rice Bioactive Peptide Binding with TLR4 to Overcome H2O2-Induced Injury in Human Umbilical Vein Endothelial Cells through NF-κB Signaling

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