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Rice Bioactive Peptide Binding with TLR4 To Overcome H2O2-Induced Injury in Human Umbilical Vein Endothelial Cells through NF-kappa B Signaling

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成果类型:
期刊论文
作者:
Liang, Ying;Lin, Qinlu*;Huang, Ping;Wang, Yugian;Li, Jiajia;...
通讯作者:
Lin, Qinlu
作者机构:
[Huang, Ping; Li, Jiajia; Cao, Jianzhong; Wang, Yugian; Zhang, Lin; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Rice & Byprod Deep Proc, Mol Nutr Branch, Changsha 410004, Hunan, Peoples R China.
[Huang, Ping; Li, Jiajia; Cao, Jianzhong; Wang, Yugian; Zhang, Lin; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Lin, Qinlu] C
Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
HUVECs;NF-kappaB (p65);Toll-like receptor 4 (TLR4);antioxidant;rice-derived bran bioactive peptide (RBAP)
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2018
卷:
66
期:
2
页码:
440-448
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31201348/31571874]; Hunan Youth Excellent Talents Supporting Program [2016RS3033]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ2410]; Central South University of Forestry and Technology [2015JC03]; Grain-oil Process and Quality Control Collaborative and Innovative Grant from Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
Reactive oxygen species-induced vessel endothelium injury is crucial in cardiovascular diseases progression. Rice-derived bran bioactive peptides (RBAP) might exert antioxidant effect through unknown mechanisms. Herein, we validated the antioxidant effect and mechanism of RBAP on H2O2-induced oxidative injury in human umbilical vein endothelial cells (HUVECs). Here, HUVECs were treated with RBAP under H2O2stimulation;the effects of RBAP on HUVECs oxidative injury were evaluated. H2O2injury-induced cell morphology changes were ameliorated by RBAP. The effect of H2O2- on HUVEC apoptosis (percent...

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