It is well known that stability, center-of-gravity balance, and concentrated-weight are key factors of the transportation safety. The reasonable formulation of the loading layout scheme ensures the safety of shipment based on fully utilizing the effective volume and load capacity of freight vehicles. This paper takes the railway mixed goods loading layout as the research object, considering the constraints such as goods loading center-of-gravity balance, the allowable moment of concentrated-weight, supporting and goods placement mode, and takin...