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Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma

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成果类型:
期刊论文
作者:
Shi, Yi;Zhang, Dan-Dan;Liu, Ji-Bin;Yang, Xiao-Li;Xin, Rui;...
通讯作者:
Li, Wen;Da, Fu;Ma, Yu-Shui
作者机构:
[Shi, Yi; Deng, Jing; Li, Zi-Jin; Li, Wen; Lin, Qin-Lu; Liu, Yu; Chen, Xiao-Qi; Da, Fu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.
[Shi, Yi; Liu, Ji-Bin] Nantong Tumor Hosp, Canc Inst, Nantong 226631, Peoples R China.
[Shi, Yi; Ma, Liang; Zheng, Xiang-Min; Li, Wen; Feng, Shan-Shan; Liu, Yu] Hunan Univ Technol, Coll Life Sci & Chem, Zhuzhou 412007, Hunan, Peoples R China.
[Zhang, Dan-Dan] Shihezi Univ, Dept Pathol, Sch Med, Shihezi 832002, Xinjiang, Peoples R China.
[Yang, Xiao-Li; Wang, Pei-Yao; Xin, Rui; Zhang, Dan-Dan; Wang, Hui-Min; Gu, Li-Peng; Da, Fu; Tian, Lin-Lin] Tongji Univ, Shanghai Peoples Hosp 10, Cent Lab Med Res, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China.
通讯机构:
[Li, Wen] C
[Da, Fu; Ma, Yu-Shui] T
Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.
Tongji Univ, Shanghai Peoples Hosp 10, Cent Lab Med Res, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China.
Tongji Univ, Shanghai Peoples Hosp 10, Dept Nucl Med, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China.
语种:
英文
关键词:
argonaute 2 protein;dleu2l protein;fam99a protein;hs3st3b1 protein;long untranslated RNA;messenger RNA;microRNA;microRNA 100;microRNA 125b;microRNA 9;microRNA 99a;mitogen activated protein kinase;nuclear receptor NR6A1;phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase;rhoq protein;taok1 protein;tumor marker;unclassified drug;Article;cancer prognosis;cell nucleus;clinical article;cytoplasm;down regulation;human;human tissue;immunohistochemistry;liver cell carcinoma;lymphocytic infiltration;methylation;overall survival;priority journal;RNA extraction;tumor microenvironment;upregulation
期刊:
Molecular Therapy - Nucleic Acids
ISSN:
2162-2531
年:
2021
卷:
23
页码:
702-718
基金类别:
This study was supported partly by grants from the National Key R&D Program of China ( 2018YFE0110200 ); the National Natural Science Foundation of China ( 81972214 , 81772932 , 81472202 , and 81302065 ); the Shanghai Natural Science Foundation ( 20ZR1472400 ); the Natural Science Foundation of Hunan Province of China ( 2020WK2020 , 2018JJ4061 , 2020JJ4278 , and 2020JJ5127 ); the Key Program of Hunan Provincial Department of Science and Technology ( 2019NK2111 ); the Scientific Research Fund of Hunan Provincial Education Department ( 18B290 ); the Zhuzhou Key Science & Technology Program of Hunan Province ( 2017 and 2019 ); the Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong ( HS2016004 ), and by the Jiangsu 333 Program ( BRA2017205 ). This study was supported partly by grants from the National Key R&D Program of China (2018YFE0110200); the National Natural Science Foundation of China (81972214, 81772932, 81472202, and 81302065); the Shanghai Natural Science Foundation (20ZR1472400); the Natural Science Foundation of Hunan Province of China (2020WK2020, 2018JJ4061, 2020JJ4278, and 2020JJ5127); the Key Program of Hunan Provincial Department of Science and Technology (2019NK2111); the Scientific Research Fund of Hunan Provincial Education Department (18B290); the Zhuzhou Key Science & Technology Program of Hunan Province (2017 and 2019); the Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong (HS2016004), and by the Jiangsu 333 Program (BRA2017205). Y.-S.M. D.F. and W.L. designed the study; Y.S. D.-D.Z. J.-B.L. X.-L.Y. R.X. C.-Y.J. H.-M.W. G.-X.L. P.-Y.W. Z.-J.L. Y.-S.M. D.F. and W.L. conducted the study; Y.S. D.-D.Z. Y.L. Z.-J.L. J.D. Q.-L.L. L.M. S.-S.F. X.-Q.C. X.-M.Z. Y.-F.Z. Y.-J.H. H.-Q.Y. L.-L.T. L.-P.G. Z.-W.L. F.Y. Y.-S.M. and D.F. collected data; Y.S, D.-D.Z. Y.-S.M. D.F. and W.L. performed the statistical analyses and interpreted the data; Y.-S.M. D.F. and W.L. contributed to study materials and consumables; and Y.S, Y.-S.M. D.F. and W.L. wrote the manuscript. All authors contributed to the final version of the manuscript and approved the final manuscript. The authors declare no competing interests.
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
Shi et al. provide evidence that a ceRNA-based DLEU2L/TAOK1 axis has an impact on changes in the tumor immune microenvironment and might be a novel important prognostic factor associated with the diagnosis and prognosis of HCC. © 2020 The Author(s)Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. However, the complexity and behavior characteristi...

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