Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Shi, Yi;Zhang, Dan-Dan;Liu, Ji-Bin;Yang, Xiao-Li;Xin, Rui;...

通讯作者：

Li, Wen;Da, Fu;Ma, Yu-Shui

作者机构：

[Shi, Yi; Deng, Jing; Li, Zi-Jin; Li, Wen; Lin, Qin-Lu; Liu, Yu; Chen, Xiao-Qi; Da, Fu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

[Shi, Yi; Liu, Ji-Bin] Nantong Tumor Hosp, Canc Inst, Nantong 226631, Peoples R China.

[Shi, Yi; Ma, Liang; Zheng, Xiang-Min; Li, Wen; Feng, Shan-Shan; Liu, Yu] Hunan Univ Technol, Coll Life Sci & Chem, Zhuzhou 412007, Hunan, Peoples R China.

[Zhang, Dan-Dan] Shihezi Univ, Dept Pathol, Sch Med, Shihezi 832002, Xinjiang, Peoples R China.

[Yang, Xiao-Li; Wang, Pei-Yao; Xin, Rui; Zhang, Dan-Dan; Wang, Hui-Min; Gu, Li-Peng; Da, Fu; Tian, Lin-Lin] Tongji Univ, Shanghai Peoples Hosp 10, Cent Lab Med Res, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China.

通讯机构：

[Li, Wen] C

[Da, Fu; Ma, Yu-Shui] T

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

Tongji Univ, Shanghai Peoples Hosp 10, Cent Lab Med Res, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China.

Tongji Univ, Shanghai Peoples Hosp 10, Dept Nucl Med, Sch Med, 36 Yunxin Rd, Shanghai 200072, Peoples R China.

语种：

英文

关键词：

HCC;ceRNA network;DLEU2L/TAOK1 axis;prognosis

期刊：

Molecular Therapy - Nucleic Acids

ISSN：

2162-2531

年：

2021

卷：

页码：

702-718

DOI：

10.1016/j.omtn.2020.12.016

基金类别：

National Key R&D Program of China [2018YFE0110200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972214, 81772932, 81472202, 81302065]; Shanghai Natural Science FoundationNatural Science Foundation of Shanghai [20ZR1472400]; Natural Science Foundation of Hunan Province of ChinaNatural Science Foundation of Hunan Province [2020WK2020, 2018JJ4061, 2020JJ4278, 2020JJ5127]; Key Program of Hunan Provincial Department of Science and Technology [2019NK2111]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [18B290]; Zhuzhou Key Science & Technology Program of Hunan Province; Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong [HS2016004]; Jiangsu 333 Program [BRA2017205]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. However, the complexity and behavior characteristics of the ceRNA network in HCC were still unclear. In this study, we aimed to clarify a phosphatase and tensin homolog (PTEN)-related ceRNA regulatory network and identify potential prognostic markers associated with HCC. The expression profiles of three RNAs (long non-coding RNAs [lncRNAs], microR...

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Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma

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