Nickel-Catalyzed C(sp3)–Sb Coupling of Chlorostibines with Unactivated Alkyl Chlorides and In Vitro Anticancer Activity of Products

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成果类型：

期刊论文

作者：

Le, Liyuan;Yin, Mingming;Zeng, Huifan;Xie, Wuxing;Zhou, Wenjun;...

通讯作者：

Qiu, RH;Chen, Y;Xiong, BQ

作者机构：

[Yin, Shuang-Feng; Yin, Mingming; Zhou, Wenjun; Qiu, Renhua; Qiu, RH; Le, Liyuan; Zeng, Huifan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

[Chen, Yi; Xie, Wuxing; Chen, Y] Hunan Univ Chinese Med, Sch Med, Dept Physiol, Changsha 410208, Peoples R China.

[Yin, Shuang-Feng] Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Peoples R China.

[Kambe, Nobuaki] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan.

[Xiong, Biquan] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China.

通讯机构：

[Qiu, RH ; Xiong, BQ ; Chen, Y ] H

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

Hunan Univ Chinese Med, Sch Med, Dept Physiol, Changsha 410208, Peoples R China.

Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China.

语种：

英文

关键词：

amine;chloride;ether derivative;nickel;catalysis;Amines;Catalysis;Chlorides;Ethers;Nickel

期刊：

Organic Letters

ISSN：

1523-7060

年：

2024

卷：

期：

页码：

344-349

DOI：

10.1021/acs.orglett.3c04008

基金类别：

The authors thank the Natural Science Foundation of China (21676076, 21878071, 21971060, 22278120), Hu-Xiang High Talent (2018RS3042), and Recruitment Program for Foreign Experts of China (WQ20164300353) for financial support.

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本校为其他机构

院系归属：

理学院

摘要：

In this study, we present a nickel-catalyzed reductive C(sp3)-Sb coupling of unactivated alkyl chlorides with chlorostibines. This approach is highly versatile, tolerating various functional groups such as acetal, alkene, nitrile, amine, ester, silyl ether, thioether, and various heterocyclic compounds. Notably, the late-stage modification of bioactive molecules and the satisfactory anticancer activity against cancerous MDA-MB-231 also demonstrate t...

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Nickel-Catalyzed C(sp3)–Sb Coupling of Chlorostibines with Unactivated Alkyl Chlorides and In Vitro Anticancer Activity of Products

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