Disruption of the Ergosterol Biosynthetic Pathway Results in Increased Membrane Permeability, Causing Overproduction and Secretion of Extracellular Monascus Pigments in Submerged Fermentation

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成果类型：

期刊论文

作者：

Liu, Jun;Chai, Xueying;Guo, Ting;Wu, Jingyan;Yang, Pengpeng;...

通讯作者：

Ling, Qinlu

作者机构：

[Dong, Jie; Guo, Ting; Wu, Jingyan; Zhao, Hui; Chai, Xueying; Bai, Jie; Zhao, Wen; Ling, Qinlu; Liu, Jun; Luo, Yunchuan; Nkechi, Omeoga] Cent South Univ Forestry & Technol, Hunan Key Lab Proc Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Natl Engn Lab Deep Proc Rice & Byprod,Coll Food S, Changsha 410004, Hunan, Peoples R China.

[Yang, Pengpeng] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhu South Rd, Nanjing 211816, Jiangsu, Peoples R China.

通讯机构：

[Ling, Qinlu] C

Cent South Univ Forestry & Technol, Hunan Key Lab Proc Food Special Med Purpose, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Natl Engn Lab Deep Proc Rice & Byprod,Coll Food S, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Monascus purpureus;ergosterol;membrane permeability;secretion mechanism

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2019

卷：

期：

页码：

13673-13683

DOI：

10.1021/acs.jafc.9b05872

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31571874]; 2011 Collaborative Innovation Center of Hunan province [448]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40542, 2018JJ3872, 2018JJ2672]; Research and Development Plan in Key Areas of Hunan Province [2019NK2111]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Because Monascus pigments (MPs) predominantly accumulate in the cytoplasm during submerged fermentation, many biotechnologies are applied to enhance the production of extracellular MPs (exMPs) to reduce the downstream processing costs. In this study, the genes monascus_7017 and monascus_8018, identified as ERG4 genes, were knocked out to disrupt the ergosterol biosynthetic pathway and enhance the production of exMPs in Monascus purpureus LQ-6. Double-deletion of EGR4 in M. purpureus LQ-6 reduced ergosterol concentration by 57.14% and enhanced exMP production 2.06-fold. In addition, integrated ...

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Disruption of the Ergosterol Biosynthetic Pathway Results in Increased Membrane Permeability, Causing Overproduction and Secretion of Extracellular Monascus Pigments in Submerged Fermentation

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