Gastrodin ameliorates exercise-induced fatigue via modulating Nrf2 pathway and inhibiting inflammation in mice

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成果类型：

期刊论文

作者：

Zhou, Yaping;Wu, Qi;Yu, Wen;Ye, Fan;Cao, Yunyun;...

通讯作者：

Luo, F.;Lin, Q.

作者机构：

[Wu, Qi; Wu, Xiuxiu; Zhou, Yaping; Luo, Feijun; Lu, Han; Xie, Tiantian; Akan, Otobong D.; Ye, Fan; Cao, Yunyun; Yu, Wen; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Ctr Deep Proc Rice & Byproducts, Hunan Prov Key Lab Grain Oil Deep Proc & Qual Cont, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

[Cao, Fuliang] Nanjing Forestry Univ, Coll Forestry, Coinnovat Ctr Sustainable Forestry Southern China, 159 Longpan Rd, Nanjing 210037, Jiangsu, Peoples R China.

[Luo, Feijun; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Feijun Luo; Qinlu Lin] N

National Engineering Center for Deep Process of Rice and Byproducts, Hunan Provincial Key Laboratory of Grain-oil Deep Process and Quality Control, Hunan Key Provincial Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, Central South University of Forestry and Technology, No. 498, Shaoshan Road, Changsha, 410004, Hunan, PR China

语种：

英文

关键词：

Anti-fatigue;Gastrodin;Molecular mechanism;Network pharmacology;Nrf2 signaling pathway

期刊：

Food Bioscience

ISSN：

2212-4292

年：

2023

卷：

页码：

102262

DOI：

10.1016/j.fbio.2022.102262

基金类别：

This work is financially supported by Program for Science & Technology Innovation Platform of Hunan Province ( 2019TP102 ), Graduate Innovative Research Project of Hunan province and Central South University of Forestry and Technology ( CX20210862 , CX202101027 ), and Science and Technology Plan Project of Changsha City ( kq2014275 ).

机构署名：

本校为第一机构

院系归属：

食品科学与工程学院

摘要：

Gastrodia elata Bl. is traditional Chinese medicine used to alleviate fatigue, but its underlying mechanism is still unclear. This study explored the anti-fatigue mechanism of gastrodin by exercise-induced fatigue model and network pharmacology. This study found that gastrodin (200 mg/kg/day) had significant anti-fatigue effects in C57BL/6J mice based on mouse energy and endurance measurements. Gastrodin could effectively ameliorate biochemical indexes in the fatigue mice. The putative targets of “Gastrodin” and “Fatigue” were obtained by i...

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Gastrodin ameliorates exercise-induced fatigue via modulating Nrf2 pathway and inhibiting inflammation in mice

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