Discovery and mechanism of anti-hypertensive effect of a novel tripeptide (SYP) from medicinal fungus Ganoderma lingzhi

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成果类型：

期刊论文

作者：

Wu, Qiang;Luo, Feijun;Huang, Jia;Huang, Ping;Liu, Yongnan;...

通讯作者：

Wang, Xiaoling;Liu, GQ

作者机构：

[Liu, Gaoqiang; Liu, GQ; Huang, Ping; Liu, Yongnan; Wang, Xiaoling; Wang, XL; Huang, Jia; Wu, Qiang] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Peoples R China.

[Liu, Gaoqiang; Liu, GQ; Huang, Ping; Liu, Yongnan; Wang, Xiaoling; Wang, XL; Huang, Jia; Wu, Qiang] Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Res, Changsha 410004, Peoples R China.

[Liu, Gaoqiang; Huang, Ping; Liu, Yongnan; Wang, Xiaoling; Huang, Jia; Wu, Qiang] Microbial Variety Creat Ctr, Lab Yuelushan Seed Ind, Changsha 410004, Peoples R China.

[Wu, Qiang] Shaoyang Univ, Coll Food & Chem Engn, Shaoyang 422000, Peoples R China.

[Luo, Feijun] Cent South Univ Forestry & Technol, Lab Mol Nutr, Natl Engn Lab Rice & Byprod, Changsha 410004, Peoples R China.

通讯机构：

[Liu, GQ ; Wang, XL] C

Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Peoples R China.

Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Res, Changsha 410004, Peoples R China.

语种：

英文

关键词：

Antihypertensive peptide;Ganoderma lingzhi;Gene microarray;Molecular mechanism

期刊：

食品科学与人类健康

ISSN：

2097-0765

年：

2025

卷：

期：

DOI：

10.26599/fshw.2024.9250032

基金类别：

National Natural Science Foundation of China [32071673, 32202573]; Program of Hunan Science and Technology Innovation Team [2021RC4063]; Natural Science Foundation of Hunan Province [2021JJ31151, 2022JJ50028]; Key Scientific Research Project of Hunan Education Department [22A0538]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma (Agaricomycetes). Using angiotensin I-converting enzyme (ACE) as a target, a tripeptide Ser-Tyr-Pro (SYP) was discovered with preponderant ACE inhibitory activity with an 50% inhibiting concentration (IC50) value of 62.50 mu g/mL attribute to the formed salt bridge and hydrogen bonds between SYP and ACE. SYP even maintained superior bioactivity after intestinal digestion, and exerted no cytotoxicity, but presented incomplete bioavailability in blood of spontaneous hypertensive rats (SHRs). Furthermore, it performed an...

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Discovery and mechanism of anti-hypertensive effect of a novel tripeptide (SYP) from medicinal fungus Ganoderma lingzhi

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