The purpose of this study was to study the transport mechanism of LSW (Leu-Ser-Trp), an angiotensin I-converting enzyme inhibitory tripeptide derived from soybean proteins, using Caco-2 cell monolayers. Antihypertensive peptide LSW at a concentration of 5 or 10 mM had no cytotoxicity on cells, and could be intact transported across Caco-2 monolayers (apparent permeability coefficient: (11.53 ± 1.82) × 10−8 cm/s), and was resistant to the peptidases in apical sides. In addition, LSW transport was significantly increased by cytochalasin D (a t...
