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miR-627/HMGB1/NF-κB regulatory loop modulates TGF-β1-induced pulmonary fibrosis

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成果类型:
期刊论文
作者:
Li, Jie;Kong, Xinyi;Jiang, Shanshan;Liao, Wenjian;Zhang, Zhihui;...
通讯作者:
Zhang, Wei;Liang, Ying
作者机构:
[Zhang, Zhihui; Li, Jie; Song, Junfu; Liao, Wenjian] Jiangxi Prov Chest Hosp, Dept Internal Med, Nanchang, Jiangxi, Peoples R China.
[Kong, Xinyi] Nanchang Univ, Dept Cardiol, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China.
[Jiang, Shanshan] Peoples Hosp Anyang City, Dept Digest Syst, Anyang, Henan, Peoples R China.
[Liang, Ying] Cent South Univ Forestry & Technol, Mol Nutr Branch, Natl Engn Lab Rice & By Prod Deep Proc, Changsha, Hunan, Peoples R China.
[Liang, Ying] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha, Hunan, Peoples R China.
通讯机构:
[Zhang, Wei] N
[Liang, Ying] C
Nanchang Univ, Dept Respirat, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China.
Cent South Univ Forestry & Technol, Dept Food Sci & Engn, 498 Shaoshan South Rd, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
advanced glycation end product receptor;alpha smooth muscle actin;collagen type 1;high mobility group B1 protein;immunoglobulin enhancer binding protein;messenger RNA;microRNA;microRNA 627;transforming growth factor beta1;unclassified drug;ACTA2 protein, human;actin;collagen type 1;high mobility group B1 protein;HMGB1 protein, human;immunoglobulin enhancer binding protein;microRNA;MIRN627 microRNA, human;transforming growth factor beta1;3' untranslated region;Article;cell proliferation;controlled study;gene expression;gene knockdown;gene overexpression;human;human cell;human tissue;in vitro study;lung fibroblast;lung fibrosis;molecular pathology;pathogenesis;priority journal;protein expression;regulatory mechanism;signal transduction;cell culture;genetics;HEK293 cell line;lung fibrosis;metabolism;Actins;Cells, Cultured;Collagen Type I;HEK293 Cells;HMGB1 Protein;Humans;MicroRNAs;NF-kappa B;Pulmonary Fibrosis;Signal Transduction;Transforming Growth Factor beta1
期刊:
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN:
0730-2312
年:
2019
卷:
120
期:
3
页码:
2983-2993
基金类别:
This study is supported by the National Natural Science Foundation (Youth Foundation) of Jiangxi Province (Grant 20181BAB215001).
机构署名:
本校为通讯机构
院系归属:
食品科学与工程学院
摘要:
Pulmonary fibrosis (PF) is a fibroproliferative disease that can eventually lead to fatal lung failure. It is characterized by abnormal proliferation of fibroblasts, dysregulated fibroblast differentiation to myofibroblast, and disorganized collagen and extracellular matrix production, deposition and degradation. There is still a lack of effective treatment strategies for PF. Extracellular high-mobility group box protein 1 (HMGB1) induces PF through NF-kappaB-mediated TGF-beta1 release. Herein, we first validate the suppressive effect of HMGB1 knockdown on TGF-beta1-induced alpha-smooth muscle...

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