Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d -Galactose

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期刊论文

作者：

Wang, Yuqian;Cui, Xiaoji;Lin, Qinlu;Cai, Jie;Tang, Liuhuan;...

通讯作者：

Liang, Ying

作者机构：

[Cui, Xiaoji; Cai, Jie; Wang, Yuqian; Tang, Liuhuan; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Mol Nutr Branch, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Liang, Ying] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Mol Nutr Branch, Natl Engn Lab Rice & Byprod Deep Proc, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Cell signaling;Enzymes;Hydrogen peroxide;Oxidative stress;Peptides;Active peptides;Cancer research;Expression levels;Malondialdehyde;Molecular mechanism;Nuclear transport;Physiologically active peptides;Super oxide dismutase;Mammals;antioxidant;galactose;immunoglobulin enhancer binding protein;malonaldehyde;peptide;reactive oxygen metabolite;superoxide dismutase;transcription factor Nrf2;aging;animal;apoptosis;chemistry;drug effect;genetics;human;Institute for Cancer Research mouse;male;metabolism;mouse;Oryza;oxidative stress;plant seed;Aging;Animals;Antioxidants;Apoptosis;Galactose;Humans;Male;Malondialdehyde;Mice;Mice, Inbred ICR;NF-E2-Related Factor 2;NF-kappa B;Oryza;Oxidative Stress;Peptides;Reactive Oxygen Species;Seeds;Superoxide Dismutase

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2020

卷：

期：

页码：

12271-12283

DOI：

10.1021/acs.jafc.0c04358

基金类别：

This work was supported by funding from the Natural Science Foundation of Hunan Province (no. 2020JJ4138), the National Natural Science Foundation of China (no. 31201348), Hunan Furong Scholars Program, Huxiang Youth Talents Supporting Program (no. 2016RS3033), Scientific Research Foundation of Hunan Provincial Education Department (no. 18A160), and Grain-oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province.

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

This study investigated the effects of a physiologically active peptide derived from rice bran (KF-8) on oxidative stress in d-galactose (d-gal)-induced aging mice and the underlying molecular mechanisms. The aging model was developed by subcutaneously injecting Institute of Cancer Research mice with 250 mg/kg d-gal daily for 12 weeks and simultaneously treating them with 30 mg/kg KF-8. The relative expression levels of Nrf2 and NF-κB in the liver were determined by the western blot. The regulation of Nrf2 and NF-κBp65 by KF-8 was further val...

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Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d -Galactose

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