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Elaboration of curcumin-loaded rice bran albumin nanoparticles formulation with increased invitro bioactivity and invivo bioavailability

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成果类型:
期刊论文
作者:
Liu, Chun;Yang, Xiaoquan;wu, Wei;Long, Zhao;Xiao, Huaxi;...
通讯作者:
Lin, Qinlu
作者机构:
[wu, Wei; Long, Zhao; Luo, Feijun; Xiao, Huaxi; Liu, Chun; Lin, Qinlu] Ctr South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & By Prod Deep Proc, Changsha 410004, Hunan, Peoples R China.
[Yang, Xiaoquan] South China Univ Technol, Sch Food Sci & Engn, Res & Dev Ctr Food Prot, Guangzhou 510640, Guangdong, Peoples R China.
[Shen, Yingbin] Jinan Univ, Sch Sci & Engn, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China.
通讯机构:
[Lin, Qinlu] C
Ctr South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & By Prod Deep Proc, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
Rice bran albumin;Curcumin;Nanoparticles;Bioactivity;Bioavailability
期刊:
Food Hydrocolloids
ISSN:
0268-005X
年:
2018
卷:
77
期:
Apr.
页码:
834-842
基金类别:
This research was supported by grants from the National Natural Science Foundation of China (No. 31571874), the Grain-oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan Province (No. 2013448) and the Special Fund for Agro-Scientific Research in the Public Interest (No. 201303071-05).
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with various bioactivities, but its optimum potential is limited by its lack of dispersibility in aqueous solvents and poor oral bioavailability. Here, we employed a protein-based nanoparticle approach to improve bioactivity and bioavailability. Curcumin was encapsulated with 95.94% efficiency in biodegradable nanoparticulate formulation based on rice bran albumin (RBA). The mean particle diameter and zeta-potential of curcumin-loaded RBA nanoparticles (Cur-RBA-NPs) were 120 nm and -36.3 mV, respectively....

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