Light-powered Escherichia coli cell division for chemical production

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期刊论文

作者：

Ding, Qiang;Ma, Danlei;Liu, Gao-Qiang;Li, Yang;Guo, Liang;...

通讯作者：

Chen, Xiulai

作者机构：

[Hu, Guipeng; Ding, Qiang; Ma, Danlei; Ye, Chao; Gao, Cong; Li, Yang; Liu, Jia; Guo, Liang; Chen, Xiulai; Liu, Liming] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.

[Hu, Guipeng; Ding, Qiang; Ma, Danlei; Ye, Chao; Gao, Cong; Li, Yang; Liu, Jia; Guo, Liang; Chen, Xiulai; Liu, Liming] Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China.

[Liu, Gao-Qiang] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Peoples R China.

[Liu, Liming] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi 214122, Jiangsu, Peoples R China.

通讯机构：

[Chen, Xiulai] J

Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.

Jiangnan Univ, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China.

语种：

英文

期刊：

Nature Communications

ISSN：

2041-1723

年：

2020

卷：

期：

DOI：

10.1038/s41467-020-16154-3

基金类别：

National Key R&D Program of China [2019YFA0904900]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21978113]; Key Technologies R&D Program of Jiangsu Province [BE2017622]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [JUSRP22031]; National First-Class Discipline Program of Light Industry Technology and Engineering [LITE2018-08]

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本校为其他机构

院系归属：

生命科学与技术学院

摘要：

Cell division can perturb the metabolic performance of industrial microbes. The C period of cell division starts from the initiation to the termination of DNA replication, whereas the D period is the bacterial division process. Here, we first shorten the C and D periods of E. coli by controlling the expression of the ribonucleotide reductase NrdAB and division proteins FtsZA through blue light and near-infrared light activation, respectively. It increases the specific surface area to 3.7 mu m(-1) and acetoin titer to 67.2g.L-1. Next, we prolong the C and D periods of E. coli by regulating the ...

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Light-powered Escherichia coli cell division for chemical production

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