Isolation and Characterization of Three Antihypertension Peptides from the Mycelia of Ganoderma Lucidum (Agaricomycetes)

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期刊论文

作者：

Wu, Qiang;Li, Yong;Peng, Kuan;Wang, Xiao-Ling*;Ding, Zhongyang;...

通讯作者：

Wang, Xiao-Ling;Liu, Gao-Qiang

作者机构：

[Li, Yong; Liu, Gao-Qiang; Peng, Kuan; Wang, Xiao-Ling; Wu, Qiang; Liu, GQ] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Hunan, Peoples R China.

[Li, Yong; Liu, Gao-Qiang; Peng, Kuan; Wang, Xiao-Ling; Wu, Qiang; Liu, GQ] Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Re, Changsha 410004, Hunan, Peoples R China.

[Wu, Qiang] Shaoyang Univ, Coll Food & Chem Engn, Shaoyang 422000, Peoples R China.

[Ding, Zhongyang; Liu, Liming] Jiangnan Univ, Natl Engn Lab Cereal Fermentat Technol, Wuxi 214122, Jiangsu, Peoples R China.

[Xu, Peng] Univ Maryland Baltimore Cty, Coll Chem Biochem & Environm Engn, Baltimore, MD 21201 USA.

通讯机构：

[Wang, XL; Liu, GQ] C

Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Hunan, Peoples R China.

Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Re, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Endothelial cells;Hydrogen bonds;Nitric oxide;Peptides;Ace inhibitory peptides;Anti-hypertension;Ganoderma Lucidum;Molecular dynamics simulations;Submerged fermentation;Molecular dynamics;antihypertensive agent;dipeptidyl carboxypeptidase;dipeptidyl carboxypeptidase inhibitor;peptide;amino acid sequence;cell line;chemistry;Ganoderma lucidum;human;isolation and purification;kinetics;mass spectrometry;metabolism;molecular dynamics;mycelium;peptide mapping;Amino Acid Sequence;Angiotensin-Converting Enzyme Inhibitors;Antihypertensive Agents;Cell Line;Humans;Kinetics;Mass Spectrometry;Molecular Dynamics Simulation;Mycelium;Peptide Mapping;Peptides;Peptidyl-Dipeptidase A;Reishi

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2019

卷：

期：

页码：

8149-8159

DOI：

10.1021/acs.jafc.9b02276

基金类别：

Financial support from the National Natural Scientific Foundation of China (31772374 and 21804145) and the Intergovernmental Key Project of the International Science and Technology Cooperation Research of China (2017YFE0108100) is gratefully acknowledged. We also thank the Foundation of Hunan International Cooperation Base of Scientific and Technological Innovation (2018WK4008), the Hunan Natural Science Foundation (2017JJ2406), and the Outstanding Youth Project of Hunan Forestry Technology Innovation Plan (XLK201944).

机构署名：

本校为第一且通讯机构

院系归属：

生命科学与技术学院

摘要：

Ganoderma lucidum (G. lucidum) has been widely used in Asia to treat hypertension, but the active substances responsible for its antihypertensive effects remain unclear. Using the well-established angiotensin I-converting enzyme (ACE) as a target, we identified three ACE inhibitory peptides (ACEIPs), Gln-Leu-Val-Pro (QLVP), Gln-Asp-Val-Leu (QDVL), and Gln-Leu-Asp-Leu (QLDL), which account for the antihypertensive activity of G. lucidum. Notably, QLVP worked in a mixed-type manner against ACE with an IC50 value of 127.9 μmol/L. Molecular dynami...

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Isolation and Characterization of Three Antihypertension Peptides from the Mycelia of Ganoderma Lucidum (Agaricomycetes)

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