The purpose of this study was to evaluate the immunomodulatory activity of oil-tea seed meal peptide (OTSMP) in mice. With spleen lymphocytes proliferation function, index of immune organ, calculation of 50% hemolysin value (HC50), phagocytic index and phagocytic rate of macrophage, swelling rate in ear of mice induced by 2, 4-Dini-trofluorobenzene (DNFB) as evaluated indices, the immunomodulatory effect of OTSMP in mice was studied with high, medium and low dose (i. e. 250, 500, 1 000 mg/kg bw) of them. The results obtained from this study showed that all of three doses of OTSMP could effecti...