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Diacylglycerol from camellia oil improves hyperuricemia by inhibiting xanthine oxidase and modulating gut microbiota

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成果类型:
期刊论文
作者:
Chen, Yajuan;Xiao, Jingjing;Zhang, Lingyu;Mu, Jianfei;Wang, Jianqiang;...
通讯作者:
Xiao, ZH;Liang, Y
作者机构:
[Zhang, Lingyu; Wang, Jianqiang; Mu, Jianfei; Yu, Xudong; Liang, Ying; Chen, Yajuan] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & By Prod Deep Proc, Mol Nutr Branch, Changsha 410004, Hunan, Peoples R China.
[Li, Li; Xiao, Zhihong; Xiao, Jingjing; Xiao, ZH] Hunan Acad Forestry, State Key Lab Utilizat Woody Oil Resource, Changsha 410004, Hunan, Peoples R China.
[Li, Li; Xiao, Zhihong; Xiao, Jingjing] Hunan Acad Forestry, Hunan Prov Key Lab Oils & Fats Mol Struct & Funct, Changsha, Peoples R China.
通讯机构:
[Liang, Y ] C
[Xiao, ZH ] H
Hunan Acad Forestry, State Key Lab Utilizat Woody Oil Resource, Changsha 410004, Hunan, Peoples R China.
Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Res Ctr Rice & By Prod Deep Proc, Mol Nutr Branch, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
Camellia oil;Diacylglycerol (DAG);Gut microbiota;Hyperuricemia (HUA);Xanthine oxidase (XOD)
期刊:
International Journal of Biological Macromolecules
ISSN:
0141-8130
年:
2025
卷:
309
期:
Pt 2
页码:
142451
基金类别:
CRediT authorship contribution statement Yajuan Chen: Writing – original draft, Software, Resources, Methodology, Data curation. Jingjing Xiao: Resources, Investigation, Data curation. Lingyu Zhang: Software, Methodology. Jianfei Mu: Resources, Investigation. Jianqiang Wang: Investigation, Formal analysis. Xudong Yu: Resources, Investigation. Li Li: Software, Methodology. Zhihong Xiao: Resources, acquisition, Conceptualization. Ying Liang: Writing – review & editing, Supervision, Project administration, Methodology, This work was supported by funding from the National Natural Science Foundation of China ( 32372349 ), Hunan Province Major Science and Technology Innovation Platform ( 2023PT1001 and 2024PT0001 ), National Key Research and Development Program of China ( 2022YFF1100203 ), Science and Technology Innovation Talent Project of Hunan Province ( 2022RC3056 ), Foundation of State Key Laboratory of Utilization of Woody Oil Resource ( ZKF202211 ) and Major scientific and technological projects in Changsha (
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
Camellia oil exhibits multiple beneficial effects on cardiovascular, glucose, and lipid metabolism. However, the impact of camellia oil and diacylglycerol (DAG), which is one of the active compounds of camellia oil, is uncertain in terms of hyperuricemia (HUA). It was found that the physicochemical characterization of camellia oil and DAG shows a rich content of unsaturated fatty acids (UFA), particularly oleic acid and linoleic acid, thereby supporting their potential in treating HUA. In hyperuricemic mice, camellia oil and DAG dose-dependently reduced urine and serum uric acid (UA), serum cr...

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