The inclusion complex formation of curcumin with beta-CD was studied by spectrophotometry, and the apparent formation constant for curcumin-beta-CD complex was determined. The stiochiometric ratio of curcumin-beta-CD complex was investigated by Job's continuous variation methods. The results showed that a 1: 1 complex between curcumin and P-CD was formed, and the apparent formation constants decreased with the increase of reaction temperature. The thermodynamic parameters, standard free energy (Delta G degrees), enthalpy (Delta H degrees) and entropy (Delta S degrees) for complex formation of ...
