Multi-omics analysis unravels positive effect of rotenone on the cordycepin biosynthesis in submerged fermentation of Cordyceps militaris

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期刊论文

作者：

Ma, You-Chu;Huang, Ping;Wang, Xiao-Ling;Liu, Gao-Qiang

通讯作者：

Liu, Gao-Qiang(gaoliuedu@csuft.edu.cn)

作者机构：

[Huang, Ping; Liu, Gao-Qiang; Ma, You-Chu; Wang, Xiao-Ling] Cent South Univ Forestry & Technol, Int Cooperat Base Sci & Technol Innovat Forest Res, Changsha 410004, Hunan, Peoples R China.

[Huang, Ping; Liu, Gao-Qiang; Ma, You-Chu; Wang, Xiao-Ling] Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Changsha 410004, Hunan, Peoples R China.

[Liu, Gao-Qiang; Ma, You-Chu; Wang, Xiao-Ling] Microbial Variety Creat Ctr, Hunan Prov Lab Yuelushan Seed Ind, Changsha 410004, Peoples R China.

通讯机构：

[Gao-Qiang Liu] I

International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology of Hunan Province, Central South University of Forestry & Technology, Changsha, Hunan 410004, China<&wdkj&>Hunan Provincial Key Laboratory of Forestry Biotechnology, Central South University of Forestry & Technology, Changsha, Hunan 410004, China<&wdkj&>Microbial Variety Creation Center, Hunan Provincial Laboratory of Yuelushan Seed Industry, Changsha 410004, China

语种：

英文

关键词：

Cordycepin biosynthesis;Cordyceps militaris;Multi-omics;Rotenone;Submerged fermentation

期刊：

Bioresource Technology

ISSN：

0960-8524

年：

2023

卷：

373

页码：

128705

DOI：

10.1016/j.biortech.2023.128705

基金类别：

This work was supported by the National Key R&D Program of Intergovernmental International Science and Technology Cooperation (No. 2017YFE0108100), the National Natural Science Foundation of China (Nos. 31772374, 32071673), the Program of Hunan Science and Technology Innovation Team (No. 2021RC4063), the Scientific Innovation Fund for Post-graduates of Central South University of Forestry and Technology (Nos. CX20201009, CX202101010), and the Postgraduate Scientific Research Innovation Project of Hunan Province (Nos. CX20200695, CX20210841).

机构署名：

本校为第一机构

院系归属：

生命科学与技术学院

摘要：

Cordycepin is the key pharmacologically active compound of Cordyceps militaris, and various fermentation strategies have been developed to increase cordycepin production. This study aimed to investigate the effect of rotenone on cordycepin biosynthesis in submerged fermentation of C. militaris, and also to explore its possible induction mechanisms via multi-omics analysis. Adding 5 mg/L rotenone significantly increased the cordycepin production by 316.09 %, along with mycelial growth inhibition and cell wall destruction. Moreover, transcriptomi...

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Multi-omics analysis unravels positive effect of rotenone on the cordycepin biosynthesis in submerged fermentation of Cordyceps militaris

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