Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer\'s Disease - 成果

Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Yin-Hua;Wang, Ning-Ning;Zou, Zhen-Xing;Zhang, Lin;Xu, Kang-Ping;...

通讯作者：

Cao, Dong-Sheng;Tan, Gui-Shan

作者机构：

[Zou, Zhen-Xing; Tan, Gui-Shan; Wang, Ning-Ning; Chen, Alex F.; Cao, Dong-Sheng; Xu, Kang-Ping; Cao, DS; Tan, GS; Deng, Yin-Hua] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China.

[Zou, Zhen-Xing; Tan, Gui-Shan] Cent South Univ, Xiangya Hosp, Pharm Dept, Changsha, Hunan, Peoples R China.

[Zhang, Lin] Cent South Univ Forestry & Technol, Coll Food Sci & Technol, Changsha, Hunan, Peoples R China.

[Chen, Alex F.; Cao, Dong-Sheng] Cent South Univ, Xiangya Hosp 3, Ctr Vasc Dis & Translat Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Cao, DS; Tan, GS; Tan, Gui-Shan; Cao, Dong-Sheng] C

Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Pharm Dept, Changsha, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 3, Ctr Vasc Dis & Translat Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Alzheimer;BACE1;MAO-B;Selaginella plants;multi-target SAR;multi-target screening

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2017

卷：

期：

AUG

页码：

539

DOI：

10.3389/fphar.2017.00539

基金类别：

This work is financially supported by the National Natural Science Foundation of China (Grants No. 81402853, 31370370, 81501619), the National Key Basic Research Program (2015CB910700), the Central South University Innovation Foundation for Postgraduate (2016zzts498), the Project of Innovation-driven Plan in Central South University, and the Postdoctoral Science Foundation of Central South University, the Chinese Postdoctoral Science Foundation (2014T70794, 2014M562142). The studies meet with the approval of the university’s review board.

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder which is considered to be the most common cause of dementia. It has a greater impact not only on the learning and memory disturbances but also on social and economy. Currently, there are mainly single-target drugs for AD treatment but the complexity and multiple etiologies of AD make them difficult to obtain desirable therapeutic effects. Therefore, the choice of multi-target drugs will be a potential effective strategy inAD treatment. To find multi-target act...

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