Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-kappa B/AP-1/STAT-1 inactivation and PPAR-7 activation

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成果类型：

期刊论文

作者：

Shi, Limin;Lin, Qinlu*;Li, Xinhua;Nie, Ying;Sun, Shuguo;...

通讯作者：

Lin, Qinlu;Luo, Feijun

作者机构：

[Wang, Long; Tang, Yiping; Luo, Feijun; Shi, Limin; Lu, Jun; Nie, Ying; Sun, Shuguo; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Coll Food Sci & Engn, Lab Mol Nutr, Changsha, Hunan, Peoples R China.

[Li, Xinhua] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha, Hunan, Peoples R China.

[Deng, Xiyun] Hunan Normal Univ, Med Coll, Dept Pathol, Changsha, Hunan, Peoples R China.

[Lin, Qinlu; Luo, FJ] Cent South Univ Forestry & Technol, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

通讯机构：

[Lin, QL; Luo, FJ] C

Cent South Univ Forestry & Technol, 498 Shaoshan Rd, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Alliin;Inflammatory bowel disease;MAPK;PPAR;Signaling

期刊：

MOLECULAR NUTRITION & FOOD RESEARCH

ISSN：

1613-4125

年：

2017

卷：

期：

页码：

1601013-

DOI：

10.1002/mnfr.201601013

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571874]; Grain-oil Process and Quality Control Collaborative and Innovative Grant from Hunan Province; Education Department of Hunan province [13A124]; Graduate Innovative Research Project of Hunan province; Central South University of Forestry and Technology [CX2016B23]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Scope In this study, the anti‐inflammatory effects and the molecular mechanism of alliin were analyzed in dextran sulfate sodium (DSS)‐induced colitis mice and lipopolysaccharide‐stimulated RAW264.7 cell model. Methods The phenotype of mice was recorded in the DSS‐induced and/or alliin (500 mg/kg) groups. Histopathological alterations were analyzed by H&E staining. MPO and MDA of colon tissues were measured. The mRNA expression levels of inflammatory factors were determined by qRT‐PCR, and protein expressions of inflammatory factors or act...

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Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-kappa B/AP-1/STAT-1 inactivation and PPAR-7 activation

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