Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Xiuxiu;Guo, Tianyi;Li, Biao;Han, Shuai;Hu, Zuomin;...

通讯作者：

Luo, Feijun;Lin, QL

作者机构：

[Wu, Xiuxiu; Zhou, Yaping; Luo, Feijun; Guo, Tianyi; Han, Shuai; Qin, Dandan; Hu, Zuomin; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Res Ctr Rice Deep Proc & Byprod, Hunan Prov Key Lab Grain Oil Deep Proc & Qual Cont, Hunan Prov Key Lab Forestry Edible Resources Safet, Changsha 410004, Peoples R China.

[Li, Biao] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Changsha 410004, Peoples R China.

[Luo, Yi] Cent South Univ, Med Coll Xiangya, Dept Clin Med, Changsha 410008, Peoples R China.

[Luo, Feijun; Lin, Qinlu; Luo, FJ] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

通讯机构：

[Lin, QL ; Luo, FJ] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China.

语种：

英文

关键词：

Parboiled rice;Blood lipids;Transcriptome;Gut microbiota;PPAR;Signaling pathway

期刊：

食品科学与人类健康

ISSN：

2213-4530

年：

2024

卷：

期：

页码：

1422-1438

DOI：

10.26599/FSHW.2022.9250120

基金类别：

Key Project of State Key R & D Program, China [2022YFF1100200]; Program for Science & Technology Innovation Platform of Hunan Province [2019TP102]; Natural Science Foundation of Hunan Province [2021JJ31075, 2019JJ50984]; Natural Science Foundation of Changsha City [kq2014275]; Scientific Innovation Fund for Postgraduates of Central South University of Forestry and Technology [CX20200699, CX202102067]; Postgraduate Scientific Research Innovation Project of Hunan Province [CX20201018, CX20210899, CX20220701, CX20220720]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

Dietary parboiled rice (PR) has a low risk of disease, but little is known about the contribution of PR to the prevention of hyperlipidemia. The potential role and underlying mechanisms of PR in hyperlipidemia were evaluated in this study. Male C57BL/6J mice were fed with a normal diet, high-fat diet (HFD) containing refined rice (HFDRR) or PR (HFDPR). It was found that PR intervention improved lipid accumulation in mice. Transcriptomic data analysis revealed that 27 genes were up-regulated (mostly involved in lipid breakdown) and 86 genes were down-regulated (mostly involved in inflammatory r...

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Parboiled rice supplementation alleviates high-fat diet-induced hyperlipidemia by regulating genes and gut microbiota in mice

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