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A Novel Prognostic Model for Gastric Cancer with EP_Dis-Based Co-Expression Network Analysis

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成果类型:
期刊论文
作者:
Xu, Yalan;Zhang, Hongyan;Cao, Dan;Ning, Zilan;Zhu, Liu;...
通讯作者:
Zhang, HY
作者机构:
[Xu, Yalan; Zhang, Hongyan; Zhang, HY; Ning, Zilan; Zhu, Liu; Liu, Xueyan] Hunan Agr Univ, Coll Informat & Intelligence, Changsha 410128, Peoples R China.
[Cao, Dan] Cent South Univ Forestry & Technol, Coll Sci, Changsha 410004, Peoples R China.
通讯机构:
[Zhang, HY ] H
Hunan Agr Univ, Coll Informat & Intelligence, Changsha 410128, Peoples R China.
语种:
英文
关键词:
gastric cancer;prognosis;ferroptosis;EP-WGCNA
期刊:
Applied Sciences-Basel
ISSN:
2076-3417
年:
2023
卷:
13
期:
12
页码:
7108-
基金类别:
Conceptualization, H.Z., Z.N. and Y.X.; methodology, H.Z., Z.N., D.C. and Y.X.; software, Y.X. and L.Z.; validation, H.Z., Z.N. and D.C.; formal analysis, Y.X., L.Z. and X.L.; investigation, H.Z. and Y.X.; resources, H.Z. and Z.N.; data curation, Y.X., L.Z. and X.L.; writing—original draft preparation, H.Z., D.C., Y.X. and L.Z.; writing—review and editing, H.Z., D.C., Z.N., L.Z. and X.L.; visualization, H.Z. and Y.X.; supervision, H.Z.; project administration, H.Z.; funding acquisition, H.Z. and D.C. All authors have read and agreed to the published version of the manuscript. This research was funded by Natural Science Foundation of Hunan Province, grant number 2021JJ30351, the Scientific Research Fund of Hunan Provincial Education Department, grant number No. 21C0133 and the Key Research and Development Program of Hunan Province, grant number 2020NK2033.
机构署名:
本校为其他机构
院系归属:
理学院
摘要:
Ferroptosis is a regulated form of cell death that involves iron-dependent lipid peroxidation. Ferroptosis-related genes (FRGs) play an essential role in the tumorigenesis of gastric cancer (GC), which is one of the most common and lethal cancers worldwide. Understanding the prognostic significance of FRGs in GC can shed light on GC treatment and diagnosis. In this study, we proposed a new gene co-expression network analysis method, namely EP-WGCNA. This method used Euclidean and Pearson weighted distance (EP_dis) to construct a weighted gene c...

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