Protective effect of soluble eggshell membrane protein hydrolysate on cardiac ischemia/reperfusion injury

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成果类型：

期刊论文

作者：

Yang, Tao;Li, Yan;Ma, Meihu;Lin, Qinlu;Sun, Shuguo;...

通讯作者：

Liu, Junwen

作者机构：

[Yang, Tao; Li, Yan; Sun, Shuguo; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Rice & By Prod Deep Proc, Changsha, Hunan, Peoples R China.

[Yang, Tao; Li, Yan; Sun, Shuguo; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha, Hunan, Peoples R China.

[Feng, Xi; Yang, Tao; Liu, Junwen; Zhang, Bin] Cent S Univ, Sch Basic Med Sci, Dept Histol & Embryol, Changsha 410013, Hunan, Peoples R China.

[Ma, Meihu] Huazhong Agr Univ, Natl R&D Ctr Egg Proc, Wuhan, Peoples R China.

通讯机构：

[Liu, Junwen] C

Cent S Univ, Sch Basic Med Sci, Dept Histol & Embryol, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

cardiomyocytes;cardioprotection;caspase;ischemia-reperfusion injury;soluble eggshell membrane protein

期刊：

Food & Nutrition Research

ISSN：

1654-6628

年：

2015

卷：

期：

页码：

Article: 28870

DOI：

10.3402/fnr.v59.28870

基金类别：

This work was supported by funding from the National Natural Science Foundation of China (81270371, 81201740, 81301997), the Special Fund for Agro-scientific Research in the Public Interest of China (201303071, 201303084), the Open-End Fund for the Valuable and Precision Instruments of Central South University, and the Grain-Oil Process and Quality Control 2011 Collaborative and Innovative Grant from Hunan province.

机构署名：

本校为第一机构

院系归属：

食品科学与工程学院

摘要：

Background: Soluble eggshell membrane protein (SEP) has been proved to hold the antioxidant activity. The functional role of SEP on cardioprotection was investigated in vivo and in vitro. Methods: Rats and cardiomyocytes were pretreated with SP2, a hydrolysate attained from SEP, and then subjected to ischemia/reperfusion (I/R) or hypoxia/reoxygenation (H/R) and hydrogen peroxide, respectively. The measurement of myocardial infarct size, cell apoptosis assay, cell viability assay, and caspase activity assay were performed on rats and cardiomyocy...

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Protective effect of soluble eggshell membrane protein hydrolysate on cardiac ischemia/reperfusion injury

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