Scientific Research Foundation of Hunan Provincial Education Department [21B0262, 22B1094]; Scientific Research Fund of Hunan Provincial Education Department [2022JJ40857]; Natural Science Foundation of Hunan Province [CX20230757]; Hunan Provincial Innovation Foundation for Postgraduate
机构署名：
本校为第一且通讯机构
院系归属：
理学院
摘要：
A novel alkyl radical-initiated alkylsulfonylation of alkenes via copper carbene coupling is developed for the synthesis of various alkyl-alkyl sulfones by employing potassium metabisulphite (K2S2O5) as a connector. In this reaction, readily available K2S2O5 not only serves as a sulfur dioxide source but is also demonstrated to be an efficient reducing agent for promoting the catalytic cycle. Notably, the late-stage modifications of bioactive molecules including estrone and cholesterol derivatives utilizing this protocol could also be achieved. Mechanistic investigations reveal that the transf...
