A Study on the Inhibition of AChE Activity by Ethanolic Extract of Tibet Wild Gymnadenia crassinervis and Its Protective and Reparative Effects on Aβ25−35‐Induced Cell Injury
Science and Technology Plan Projects of Tibet Autonomous Region [XZ202201ZD0001N]; Science and Technology Planning Projects of the Tibet Autonomous Region
机构署名：
本校为第一且通讯机构
院系归属：
食品科学与工程学院
摘要：
It is of great significance to develop natural active substances for treating Alzheimer's disease (AD). We constructed an AD cell model using A beta(25-35)-induced PC12 cells to assess isolated components from Tibet wild Gymnadenia crassinervis protective and reparative effects against A beta(25-35)-induced cell injury. The results indicated that the active fraction extracted and isolated from Gymnadenia crassinervis strongly inhibited acetylcholinesterase (AChE) with an excellent IC50 value as low as 135.86 +/- 5.59 mu g/mL. The main compound of the Gymnadenia crassinervis active fraction was...
