期刊论文

Kuang, Z.

英文

FRONTIERS IN ONCOLOGY

2234-943X

2022

12

987609

10.3389/fonc.2022.987609

This work was supported in part by the National Natural Science Foundation of China under Grants Nos. 62072477, 61309027, 61702562 and 61702561, the Hunan Provincial Natural Science Foundation of China under Grants No.2018JJ3888, the Scientific Research Fund of Hunan Provincial Education Department under Grant No.18B197, the National Key R&D Program of China under Grant No.2018YFB1700200, the Open Research Project of Key Laboratory of Intelligent Information Perception and Processing Technology (Hunan Province) under Grant No.2017KF01, the Hunan Key Laboratory of Intelligent Logistics Technology 2019TP1015.

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In recent years, the miRNA is considered as a potential high-value therapeutic target because of its complex and delicate mechanism of gene regulation. The abnormal expression of miRNA can cause drug resistance, affecting the therapeutic effect of the disease. Revealing the associations between miRNAs-drug resistance can help in the design of effective drugs or possible drug combinations. However, current conventional experiments for identification of miRNAs-drug resistance are time-consuming and high-cost. Therefore, it’s of pretty realistic ...