Schizophyllum commune polysaccharide ameliorates diet-induced obesity by regulating the Faecalibaculum rodentium/indole-3-lactic acid/microRNA axis

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成果类型：

期刊论文

作者：

Chaomin Yin;Chen Li;Xiuzhi Fan;Defang Shi;Jiangtao Li;...

通讯作者：

Chaomin Yin<&wdkj&>Wei Yu<&wdkj&>Hong Gao

作者机构：

[Chen Li] National Research and Development Center for Edible Fungi Processing (Wuhan), Institute of Agro-Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, 430064, China

Key Laboratory of Agro-Products Cold Chain Logistics, Ministry of Agriculture and Rural Affairs, Wuhan, 430064, China

[Jiangtao Li] College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, China

[Chaomin Yin; Xiuzhi Fan; Defang Shi; Jianhui Qiu; Fen Yao; Wei Yu; Hong Gao] National Research and Development Center for Edible Fungi Processing (Wuhan), Institute of Agro-Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, 430064, China<&wdkj&>Key Laboratory of Agro-Products Cold Chain Logistics, Ministry of Agriculture and Rural Affairs, Wuhan, 430064, China

通讯机构：

[Chaomin Yin; Wei Yu; Hong Gao] N

National Research and Development Center for Edible Fungi Processing (Wuhan), Institute of Agro-Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Sciences, Wuhan, 430064, China<&wdkj&>Key Laboratory of Agro-Products Cold Chain Logistics, Ministry of Agriculture and Rural Affairs, Wuhan, 430064, China

语种：

英文

期刊：

Carbohydrate Polymers

ISSN：

0144-8617

年：

2026

卷：

371

页码：

124436

DOI：

10.1016/j.carbpol.2025.124436

基金类别：

CRediT authorship contribution statement Chaomin Yin: Writing – review & editing, Writing – original draft, Visualization, Methodology, acquisition, Conceptualization. Chen Li: Methodology, Investigation, Formal analysis, Data curation. Xiuzhi Fan: Visualization, Methodology, Formal analysis. Defang Shi: Methodology, Investigation, Formal analysis. Jiangtao Li: Visualization, Methodology, Formal analysis. Jianhui Qiu: Investigation, Formal analysis. Fen Yao: Investigation, Formal analysis. Wei Yu: Investigation, Formal

机构署名：

本校为其他机构

院系归属：

食品科学与工程学院

摘要：

Diet-induced metabolic disorder is a global health concern, and bioactive polysaccharides have been shown to mitigate metabolic disorder by modifying gut microbiota. Polysaccharides from Schizophyllum commune have shown excellent anti-obesity effects, but the specific regulatory mechanisms remain unclear. Herein, we reported that SCP could effectively inhibit 3 T3-L1 preadipocyte differentiation in vitro and supplementation with SCP alleviated obesity in HFD-fed mice. SCP treatment significantly enriched Faecalibaculum rodentium and ILA and inc...

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Schizophyllum commune polysaccharide ameliorates diet-induced obesity by regulating the Faecalibaculum rodentium/indole-3-lactic acid/microRNA axis

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