Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Kui;Ge, Yongmei;Yang, Yongshuai;Li, Zhenjian;Liu, Jiayi;...

通讯作者：

Tang, B;Ngan, AHW

作者机构：

[Ge, Yongmei; Yang, Yongshuai; Zhang, Yuanjun; Li, Zhenjian; Wang, Kui; Xue, Yizebang; Tang, Bin; Liu, Jiayi] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China.

[Ngan, AHW; Ngan, A. H. W.; Wang, Kui] Univ Hong Kong, Dept Mech Engn, Hong Kong 999077, Peoples R China.

[Pang, Xiangchao; Tang, Bin] Shenzhen Key Lab Cell Microenvironm, Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Shenzhen 518055, Peoples R China.

[Pang, Xiangchao] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Peoples R China.

通讯机构：

[Ngan, AHW ] U

[Tang, B ] S

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China.

Univ Hong Kong, Dept Mech Engn, Hong Kong 999077, Peoples R China.

Shenzhen Key Lab Cell Microenvironm, Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

endothelial cell;hyperglycemia;stiffness;migration;Cdc42

期刊：

再生生物材料(英文版)

ISSN：

2056-3418

年：

2024

卷：

页码：

rbae004

DOI：

10.1093/rb/rbae004

基金类别：

This study is financially supported by the National Key Research and Development Program of China grants (Project No. 2019YFA0906004), the National Foundation of Science, Technology (Project No. 11872200), Guangdong Provincial Key Laboratory of Advanced Biomaterials (Project No. 2022B1212010003), the Shenzhen Science and Technology Innovation Committee (Project No. KCXFZ20211020174805009, JSGG20200225151916021) and Presidential Foundation of Zhujiang Hospital (yzjj2022 ms08).

机构署名：

本校为其他机构

院系归属：

材料科学与工程学院

摘要：

Diabetes is one of the most prevalent diseases worldwide. The tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction, and this leads to various clinical complications including diabetic foot ulcers. The vascular endothelial cells, which compactly line the inner surface of blood vessels, are responsible for the growth and maintenance of blood vessels and play an essential role in tissue regeneration. Although the mechanical properties of cells are generally known to be regulated by physiological/pathological conditions, few studies have been ...

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Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration

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