期刊论文

Application of enzyme-instructed supramolecular self-assembly in biomedicine

Gao, Yuan(gaoy@nanoctr.cn);Xie, Jianjun(xiejianjun12@sina.com)

中文

化工进展

1000-6613

2020

39

11

4568-4574

10.16085/j.issn.1000-6613.2020-0076

21675036:国家自然科学基金 51903064:国家自然科学基金 7204286:北京市自然科学基金

本校为第一机构

自组装是自然界的普遍现象,也是构建超分子生物材料的有力工具。在众多方法中,酶催化超分子自组装具有优异的肿瘤靶向性及良好的生物安全性,是近年来癌症诊疗的一个重要新方向。针对这一趋势,本文简介了酶催化超分子自组装在细胞内、外的构建方法,详细总结了其在癌症诊疗中的应用。研究表明,酶催化超分子自组装材料在生物医学成像、选择性杀死癌细胞、药物递送和克服药物不良反应方面具有潜在的应用价值。提出了体内超分子组装体的微观形貌需要明确表征、构建自组装方法的酶范围需要扩展以及需要探索酶催化超分子自组装（EISA）与亚细胞器的相互作用等解决其发展中的问题的思路和方向,并对其在抗...

Self-assembly is a common phenomenon in nature and it is also a powerful tool for building supramolecular biomaterials. Among diverse anticancer strategies, enzyme-instructed supramolecular self-assembly has shown the advantages of tumor specificity and biocompatibility, thus emerging as one of the most attractive methodology for anticancer applications. According to this trend, this review summarizes the construction of intracellular/extracellular enzymatic-instructed supramolecular self-assembly and the potential applications in the field of ...