期刊论文

中文

食品与生物技术学报

1673-1689

2022

41

5

11-19

10.3969/j.issn.1673-1689.2022.05.002

2021JJ60040:湖南省自然科学基金科教联合基金项目 20C0686:湖南省教育厅科学研究项目

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病原微生物引起的感染性疾病严重威胁人类公共安全,特别是多重耐药性细菌。抗菌肽可使细菌不产生耐药性或降低耐药性,而且具有热稳定性好、抑菌活性高、特异性强、对哺乳动物细胞毒副作用少等优势,具有主动防御和免疫等生理功能,有望成为抗菌药物最理想替代品。抗菌肽对细胞具有多靶点单独或协同抑菌作用,因此研究抗菌肽多作用靶点抑菌机制对抗菌肽应用研究具有重要指导意义。作者从细胞壁损伤机制、细胞膜损伤机制、胞内生物大分子合成影响机制、物质与能量代谢关键酶活性影响机制、线粒体损伤机制和免疫调节机制等多作用抑菌靶点视角对抗菌肽抑菌机理进行了系统综述,并对抗菌肽抑菌机理研究进...

The infectious diseases caused by pathogenic microorganisms seriously threaten human public safety,especially the multi-drug resistant bacteria(MDR).Antimicrobial peptides(AMPs)have attracted much attention because their non-drug resistance or lower drug resistance for bacteria with the advantages of good thermal stability,high antimicrobial activity,high specificity and few mammalian cytotoxic side effects.AMPs have the physiological functions of active defense and immunity,and are expected to be ideal antibiotic substitutes.AMPs possess single or synergistic bacteriostasis effect on cells wi...