By applying the density functional theory and the nonequilibrium Green's function formalism, we analyze the thermal, electrical transport properties and their applications of four kinds of bases in DNA sandwiched between two zigzag-edge graphene nanoribbon electrodes. The results show that the currents in different base-sandwiched systems display different current bias voltage characteristics. Conductivity enhancement and negative differential resistance (NDR) behaviors can be observed. The electron transport is relatively smooth, while the pho...