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Microemulsion-Confined Assembly of Magnetic Nanoclusters for pH/H2O2Dual-Responsive T2-T1 Switchable MRI

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成果类型:
期刊论文
作者:
Liu, Wei;Yin, Sheng-Yan;Hu, Yingcai;Deng, Ting;Li, Jishan*
通讯作者:
Li, Jishan
作者机构:
[Yin, Sheng-Yan; Hu, Yingcai; Li, Jishan; Liu, Wei] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Peoples R China.
[Deng, Ting] Cent South Univ Forestry & Technol, Sch Sci, Inst Appl Chem, Changsha 410004, Peoples R China.
通讯机构:
[Li, JS ] H
Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Peoples R China.
语种:
英文
关键词:
T2−T1 switchable;controllable aggregation;independent modification;magnetic resonance imaging;microemulsion;ultrasmall superparamagnetic iron oxide nanoparticles)
期刊:
ACS Applied Materials & Interfaces
ISSN:
1944-8244
年:
2022
卷:
14
期:
2
页码:
2629-2637
基金类别:
NSFCNational Natural Science Foundation of China (NSFC) [21775035]; Hunan Provincial Science and Technology Foundation [2020SK2096, 2021JJ31137]; Changsha Municipal Natural Science Foundation [Kq2014149]
机构署名:
本校为其他机构
院系归属:
理学院
摘要:
In this work, a T2-T1 switchable superparamagnetic iron oxide nanoprobe with a pH/H2O2 dual response was obtained using a microemulsion method. This novel method for the controllable assembly of small iron clusters followed by their independent modification was reported, which could not be prepared by common synthetic methods. The size of the assembled nanoprobe was uniform and controllable, with a stable T2 magnetic resonance imaging (MRI) signal under a single condition. When the nanoprobe was exposed to the tumor environment, the higher H+ a...

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