National Key Research and Development Program [2016YFA0301500]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11775301]
机构署名：
本校为其他机构
院系归属：
材料科学与工程学院
摘要：
Changes of affinity of kinesin head to microtubule regulated by changes in the nucleotide state are essential to processive movement of kinesin on microtubule. Here, using all-atom molecular dynamics simulations we show that besides the nucleotide state, large conformational changes of microtubule-tubulin heterodimers induced by strong interaction with the head in strongly binding state are also indispensable to regulate the affinity of the head to the tubulin. In strongly binding state the high affinity of the head to microtubule arises largely from mutual conformational changes of the microt...
