A mitochondrion-targeting turn-on fluorescent probe detection of endogenous hydroxyl radicals in living cells and zebrafish

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成果类型：

期刊论文

作者：

Yuan, Gangqiang;Ding, Haiyuan;Sun, Hongyan;Zhou, Liyi*;Lin, Qinlu

通讯作者：

Zhou, Liyi

作者机构：

[Yuan, Gangqiang; Zhou, Liyi; Ding, Haiyuan; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Hunan Key Lab Proc Food Spec, Changsha 410004, Hunan, Peoples R China.

[Sun, Hongyan] City Univ Hong Kong, Dept Chem, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China.

[Sun, Hongyan] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China.

[Sun, Hongyan] City Univ Hong Kong, Shenzhen Res Inst, Biotech & Hlth Ctr, Key Lab Biochip Technol, Shenzhen 518057, Peoples R China.

通讯机构：

[Zhou, Liyi] C

Cent South Univ Forestry & Technol, Natl Engn Lab Deep Proc Rice & Byprod, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Coll Food Sci & Engn,Hunan Key Lab Proc Food Spec, Changsha 410004, Hunan, Peoples R China.

语种：

英文

关键词：

Hydroxyl radical (center dot OH);Mitochondrion-targeting;Fluorescent probe;Bioimaging;Zebrafish

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2019

卷：

296

页码：

126706

DOI：

10.1016/j.snb.2019.126706

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21605046, 21572190, 21778044, 81501619, 21804145]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017JJ3060]; Shenzhen Basic Research Project [JCYJ20160601173218804]; grain-oil process and quality control 2011 collaborative and innovative grant from Hunan Province [448, 2013]; Science and Technology Innovation Platform and Talent Project of Hunan Province [2017TP1021]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Detection and imaging of hydroxyl radical (center dot OH) with high sensitivity and selectivity in biological systems is of great importance in evaluating the role of center dot OH plays in the physiological and pathological processes. Herein, a novel mitochondrion-targeting turn-on fluorescent probe RThy, has been developed to detect center dot OH in living cells and zebrafish. Probe's turn on mechanism is based on the cleavage of azo-bond by center dot OH. In RThy sensing system, possessing two groups: a lipophilic cation as a targeting-group, and an azo group acts not only as a quenching-gr...

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A mitochondrion-targeting turn-on fluorescent probe detection of endogenous hydroxyl radicals in living cells and zebrafish

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