Parboiled rice extracts ameliorate oleic acid-induced steatosis of HepG2 cell and its molecular mechanism

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成果类型：

期刊论文

作者：

Wu, Xiuxiu;Li, Biao;Lu, Han;Ling, Xuke;Hu, Zuomin;...

通讯作者：

Luo, Feijun;Lin, QL

作者机构：

[Yang, Feiyan; Tang, Yiping; Luo, Feijun; Lu, Han; Ling, Xuke; Xie, Tiantian; Lin, Qinlu; Wu, Qi; Wu, Xiuxiu; Qin, Dandan; Hu, Zuomin] Cent South Univ Forestry & Technol, Natl Res Ctr Rice Deep Proc & Byprod, Hunan Prov Key Lab Grain Oil Deep Proc & Qual Cont, Hunan Prov Key Lab Forestry Edible Resources Safet, Changsha 410004, Hunan, Peoples R China.

[Li, Biao] Cent South Univ Forestry & Technol, Coll Life Sci & Technol, Changsha 410004, Hunan, Peoples R China.

[Luo, Yi] Cent South Univ, Med Coll Xiangya, Dept Clin Med, Changsha 410008, Hunan, Peoples R China.

[Luo, Feijun; Lin, Qinlu; Luo, FJ] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Peoples R China.

通讯机构：

[Lin, QL ; Luo, FJ] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, 498 Shaoshan Rd, Changsha 410004, Peoples R China.

语种：

英文

关键词：

Parboiled rice;Lipid metabolism;LC-MS/MS;Network pharmacology;Molecular docking;PI3K-Akt

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2023

卷：

110

页码：

105853

DOI：

10.1016/j.jff.2023.105853

基金类别：

National Key R & D Program of China [2022YFF1100200]; Program for Science & Tech- nology Innovation Platform of Hunan Province [2019TP102]; Natural Science Foundation of Hunan Province [2021JJ31075, 2019JJ50984]; Natural Science Foundation of Changsha City [kq2014275]; Post- graduate Scientific Research Innovation Project of Hunan Province [CX20220701, CX20220720]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

This study assessed the potential role of parboiled rice (PR) in balancing lipid levels and its mechanisms. Water and 80% methanol soluble substances of refined rice (RR) and PR were extracted and were used to treat HepG2 cells, and PR extracts were found to alleviate cellular lipid accumulation. The components of RR and PR extracts were identified. Among them, there were 267 and 291 different components in water extract and 80% methanol extract, respectively. After screening differential substances, the active ingredients delphinidin and cinnamic acid were selected and their lipid-lowering ac...

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Parboiled rice extracts ameliorate oleic acid-induced steatosis of HepG2 cell and its molecular mechanism

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