This research proposed a green and efficient enzyme-assisted steam distillation (EASD) method for extracting essential oils from Cinnamomum camphora leaves, and a novel neural network model was constructed to precisely optimize the extraction process parameters. The results demonstrated that the artificial neural network and genetic algorithm (GA-ANN) model exhibited higher accuracy and reliability than traditional models. The optimized conditions were as follows: distillation time 4.0 h, liquid–solid ratio 13.469 mL/g, incubation time 1.511 h...